Variability of lipid hydroperoxides in pregnant and nonpregnant women

Lipid peroxidation is thought to be important in numerous disease states, including pregnancy complications. Study of its role requires markers, but the variability of available markers in non-diseased populations has not been well-characterized. We examined the variability over time of blood lipid...

Full description

Saved in:
Bibliographic Details
Published in:Reproductive toxicology (Elmsford, N.Y.) N.Y.), 1999-01, Vol.13 (1), p.41-44
Main Authors: Gladen, Beth C, Tabacova, Sonia, Baird, Donna D, Little, Ruth E, Balabaeva, Liudmila
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cell metabolism, cell oxidation
Cell physiology
Circadian Rhythm
Female
Fundamental and applied biological sciences. Psychology
Humans
Lipid Peroxidation
Lipid peroxides
Lipid Peroxides - blood
Molecular and cellular biology
Oxidative Stress
pregnancy
Pregnancy - blood
Seasons
Time Factors
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Lipid peroxidation is thought to be important in numerous disease states, including pregnancy complications. Study of its role requires markers, but the variability of available markers in non-diseased populations has not been well-characterized. We examined the variability over time of blood lipid hydroperoxides, as measured by iodometric analysis, in 49 healthy young women, 21 nonpregnant and 28 pregnant. Lipid hydroperoxides from the same woman were very similar from one day to the next but were less stable over periods of a month or more. The correlation between measurements on consecutive days was 0.98; the correlation between measurements a month or more apart was 0.11. Variability over time was not attributable to seasonal effects or, among the pregnant women, to differences over the course of pregnancy. Knowledge of the variability of this and other markers of oxidative damage enables the development of appropriate study designs.
ISSN:0890-6238
1873-1708
DOI:10.1016/S0890-6238(98)00054-9