Thymus Exosomes-Like Particles Induce Regulatory T Cells

Exosomes released from different types of cells have been proposed to contribute to intercellular communication. We report that thymic exosome-like particles (ELPs) released from cells of the thymus can induce the development of Foxp3(+) regulatory T (Treg) cells in the lung and liver. Thymic ELPs a...

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Published in:The Journal of immunology (1950) 2008-10, Vol.181 (8), p.5242-5248
Main Authors: Wang, Gui-Jun, Liu, Yuelong, Qin, Aijian, Shah, Spandan V, Deng, Zhong-bin, Xiang, Xiaoyu, Cheng, Ziqiang, Liu, Cunren, Wang, Jianhua, Zhang, Liming, Grizzle, William E, Zhang, Huang-Ge
Format: Article
Language:English
Subjects:
Animals
Female
Forkhead Transcription Factors
Liver - cytology
Liver - immunology
Lung - cytology
Lung - immunology
Mice
Mice, Inbred BALB C
T-Lymphocytes, Regulatory - cytology
T-Lymphocytes, Regulatory - immunology
Thymus Gland
Transforming Growth Factor beta - immunology
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Summary:Exosomes released from different types of cells have been proposed to contribute to intercellular communication. We report that thymic exosome-like particles (ELPs) released from cells of the thymus can induce the development of Foxp3(+) regulatory T (Treg) cells in the lung and liver. Thymic ELPs also induce the conversion of thymic CD4(+)CD25(-) T cells into Tregs. Tregs induced by thymic ELPs suppress the proliferation of CD4(+)CD25(-) T cells in vitro and in vivo. We further show that neutralization of TGF-beta in ELPs partially reverses thymic ELP-mediated induction of CD4(+)Foxp3(+) T cells in the lung and liver. This study demonstrates that thymic ELPs participate in the induction of Foxp3(+) Tregs. Also, TGF-beta of thymic ELPs might be required for the generation of Tregs in the peripheral tissues.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.181.8.5242