Maternal Lyme disease and congenital heart disease: A case-control study in an endemic area

Objective: The purpose of this study was to determine whether maternal Lyme disease increases the risk of congenital heart defect. Study Design: This retrospective case-control study was carried out at a medical center in a suburban area where Lyme disease is endemic. Case patients comprised 796 chi...

Full description

Saved in:
Bibliographic Details
Published in:American journal of obstetrics and gynecology 1999-03, Vol.180 (3), p.711-716
Main Authors: Strobino, Barbara, Abid, Syed, Gewitz, Michael
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cardiology. Vascular system
Case-Control Studies
Child
Child, Preschool
Congenital heart defect
Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava
Endemic Diseases
Female
Heart
Heart Defects, Congenital - epidemiology
Heart Defects, Congenital - etiology
Humans
Infant
Infant, Newborn
Logistic Models
Lyme disease
Lyme Disease - complications
Lyme Disease - epidemiology
Medical Records
Medical sciences
New York - epidemiology
Odds Ratio
population study
Pregnancy
Pregnancy Complications, Infectious
Retrospective Studies
Surveys and Questionnaires
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: The purpose of this study was to determine whether maternal Lyme disease increases the risk of congenital heart defect. Study Design: This retrospective case-control study was carried out at a medical center in a suburban area where Lyme disease is endemic. Case patients comprised 796 children with a diagnosis of congenital cardiac anomaly. Control subjects comprised 704 children without cardiac defects selected from the records of the same pediatric cardiology service. Maternal histories were obtained through a mailed questionnaire survey. Unconditional logistic regression analyses examined the relationship between a history of preconception and prenatal clinical Lyme disease or tick bite and case or control status. Results: There was no association between congenital heart defect and maternal tick bite (adjusted odds ratio 1.1, 95% confidence interval 0.5-2.5) or maternal Lyme disease within 3 months of conception or during pregnancy (adjusted odds ratio 0.9; 95% confidence interval 0.2-3.6). Conclusion: A woman who has been bitten by a tick or is treated for Lyme disease during or before pregnancy is not at increased risk for giving birth to a child with a congenital heart defect. (Am J Obstet Gynecol 1999;180:711-6.)
ISSN:0002-9378
1097-6868
DOI:10.1016/S0002-9378(99)70277-2