Surgical salvage of recurrent rectal carcinoma after curative resection: a 10-year experience

• Published in: Annals of surgical oncology 1999-03, Vol.6 (2), p.171-177
• Main Authors: Salo, J C, Paty, P B, Guillem, J, Minsky, B D, Harrison, L B, Cohen, A M
• Format: Article
• Language: English
• Subjects: Combined Modality Therapy; Female; Humans; Male; Middle Aged; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - surgery; Neoplasm Staging; Proportional Hazards Models; Rectal Neoplasms - pathology; Rectal Neoplasms - surgery; Retrospective Studies; Salvage Therapy; Statistics, Nonparametric; Survival Analysis
• ISSN: 1068-9265; 1534-4681
• DOI: 10.1007/s10434-999-0171-8

Local recurrence after resection of rectal carcinoma is a difficult clinical problem that adversely affects both survival and quality of life. Surgical resection is possible for a subset of patients with localized recurrences. We reviewed our experience with surgical salvage of recurrent rectal carcinoma, to determine predictors of resectability and postsalvage survival rates. A 10-year, retrospective analysis of 131 patients who underwent exploration with curative intent for local recurrence after radical resection of rectal carcinomas, in a single referral institution, was performed. Preoperative and pathological factors were examined for their ability to predict postresection survival rates and resectability. The overall 5-year survival rate for patients who underwent exploration with curative intent was 24%. Resection of recurrent disease was possible for 103 of 131 (79%) patients, with a resulting 5-year survival rate of 31%. Patients who were treated initially with abdomino-perineal resection (n = 35) presented later and were less likely to have resectable tumors than were those treated initially with some form of sphincter-preserving resection (n = 96). Among patients who could undergo resection, normal carcinoembryonic antigen levels and recurrent disease limited to the bowel wall were both favorable features. Surgical salvage of local recurrence after radical resection of rectal carcinoma can be performed safely and can result in substantial long-term survival benefits for selected patients.