Evaluation of dysthymic disorder with technetium-99 m hexamethylpropylene amine oxime brain single-photon emission tomography

Dysthymic disorder is a chronic disorder characterised by the presence of a depressed mood and is classified as a distinct category in DSM-IV, separately from major depression. Although brain imaging studies have been performed in major depressive disease, there have to date been no reports of such...

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Bibliographic Details
Published in:European journal of nuclear medicine 1999-03, Vol.26 (3), p.260-264
Main Authors: SARIKAYA, A, KARASIN, E, CERMIK, T. F, ABAY, E, BERKARDA, S
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Brain - diagnostic imaging
Case-Control Studies
Cerebrovascular Circulation
Depressive Disorder - diagnostic imaging
Dysthymic Disorder - diagnostic imaging
Female
Humans
Male
Medical sciences
Miscellaneous
Mood disorders
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Radiopharmaceuticals
Technetium Tc 99m Exametazime
Tomography, Emission-Computed, Single-Photon
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Summary:Dysthymic disorder is a chronic disorder characterised by the presence of a depressed mood and is classified as a distinct category in DSM-IV, separately from major depression. Although brain imaging studies have been performed in major depressive disease, there have to date been no reports of such studies in dysthymic disorder. In this study 36 patients with dysthymic disorder were compared with 16 normal subjects using technetium-99m hexamethylpropylene amine oxime brain single-photon emission tomography. A relative blood flow ratio was calculated for each region of interest using the average tissue activity in the region divided by activity in the cerebellum. There were significant differences in the bilateral inferior frontal, bilateral parietal, right superior frontal and left posterior temporal regions in the patients with dysthymic disorder compared with the healthy controls. These findings support the hypothesis that the biological bases for dysthymic disorder and major depression are similar. Recognition of these regional abnormalities may have clinical utility in both the diagnosis and the treatment of dysthymic disorder. Further studies are needed to confirm our results and to assess the influence of treatment in patients with dysthymic disorder.
ISSN:0340-6997
1619-7070
1619-7089
DOI:10.1007/s002590050386