Interleukin-18 and interleukin-1β : Two cytokine substrates for ICE (Caspase-1)

This special article deals with the role of processing enzymes in the generation of bioactive cytokines, particularly IL-1 beta and the novel cytokine IL-18, which was formerly called IFN gamma-inducing factor (IGIF). The "classical" pathways of cytokine processing are described, as well a...

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Bibliographic Details
Published in:Journal of clinical immunology 1999, Vol.19 (1), p.1-11
Main Authors: FANTUZZI, G, DINARELLO, C. A
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Analysis of the immune response. Humoral and cellular immunity
Animals
Biological and medical sciences
Caspase 1 - metabolism
Caspase-1
Enzymes
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
IL-1β
Immunobiology
Interleukin 18
Interleukin 18 receptors
Interleukin-1 - metabolism
Interleukin-18 - metabolism
Lymphokines, interleukins ( function, expression)
Macrophages - immunology
Mice
Molecular Sequence Data
Monocytes - immunology
Regulatory factors and their cellular receptors
Signal Transduction
γ-Interferon
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Summary:This special article deals with the role of processing enzymes in the generation of bioactive cytokines, particularly IL-1 beta and the novel cytokine IL-18, which was formerly called IFN gamma-inducing factor (IGIF). The "classical" pathways of cytokine processing are described, as well as the importance of alternative cleavage enzymes. The topic of this review also concerns the biology of IL-18. The regulation of IL-18 production, the IL-18 receptor complex, and the biological effects of this novel cytokine are described.
ISSN:0271-9142
1573-2592
DOI:10.1023/A:1020506300324