Endothelial reactivity and cardiac risk factors in older patients with peripheral arterial disease

Peripheral arterial disease (PAD) is a major cause of morbidity and mortality. Endothelium-dependent vasoreactivity, which is advocated as a measure of vascular health, is impaired in persons with cardiac risk factors and coronary artery disease. Few studies have examined the degree of endothelial d...

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Bibliographic Details
Published in:The American journal of cardiology 1999-03, Vol.83 (5), p.754-758
Main Authors: Yataco, Alberto Rafael, Corretti, Mary Concepta, Gardner, Andrew William, Womack, Christopher Joseph, Katzel, Leslie Ira
Format: Article
Language:English
Subjects:
Age Factors
Aged
Arterial Occlusive Diseases - complications
Arterial Occlusive Diseases - diagnostic imaging
Arterial Occlusive Diseases - physiopathology
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Blood Flow Velocity - physiology
Blood Glucose - analysis
Blood Pressure - physiology
Brachial Artery - diagnostic imaging
Brachial Artery - physiopathology
Cardiology. Vascular system
Cardiovascular disease
Case-Control Studies
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Coronary Disease - etiology
Coronary Disease - physiopathology
Endothelium, Vascular - diagnostic imaging
Endothelium, Vascular - physiopathology
Fasting
Female
Forecasting
Health risk assessment
Heart Diseases - etiology
Heart Diseases - physiopathology
Humans
Hyperemia - diagnostic imaging
Hyperemia - physiopathology
Male
Medical sciences
Middle Aged
Older people
Patients
Peripheral Vascular Diseases - complications
Peripheral Vascular Diseases - diagnostic imaging
Peripheral Vascular Diseases - physiopathology
Prevalence
Regional Blood Flow - physiology
Regression Analysis
Risk Factors
Smoking - physiopathology
Ultrasonography
Vasodilation - physiology
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Summary:Peripheral arterial disease (PAD) is a major cause of morbidity and mortality. Endothelium-dependent vasoreactivity, which is advocated as a measure of vascular health, is impaired in persons with cardiac risk factors and coronary artery disease. Few studies have examined the degree of endothelial dysfunction in patients with PAD. Using high-resolution external vascular ultrasound, we measured brachial artery diameter and flow at rest, and in response to reactive hyperemia (flow-mediated dilation) in 50 older patients (age 69 ± 1 year) with PAD (ankle-to-brachial artery index of 0.67 ± 0.03), and 50 age-matched non-PAD patients. Coronary artery disease was more prevalent in PAD than in non-PAD patients (40% vs 4%, p
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(98)00984-9