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The effects of obesity and non-pharmacological weight loss on vascular and ventricular function and structure
Aims: The mechanisms by which obesity confers increased cardiovascular risk and the effects of moderate weight loss on cardiovascular health are incompletely understood. We sought to characterize the preclinical changes in cardiac and vascular health that accompany obesity and the influence of life...
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| Published in: | Diabetes, obesity & metabolism obesity & metabolism, 2008-10, Vol.10 (10), p.874-884 |
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| container_issue | 10 |
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| container_title | Diabetes, obesity & metabolism |
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| creator | Skilton, M. R. Sieveking, D. P. Harmer, J. A. Franklin, J. Loughnan, G. Nakhla, S. Sullivan, D. R. Caterson, I. D. Celermajer, D. S. |
| description | Aims: The mechanisms by which obesity confers increased cardiovascular risk and the effects of moderate weight loss on cardiovascular health are incompletely understood. We sought to characterize the preclinical changes in cardiac and vascular health that accompany obesity and the influence of lifestyle modification on these parameters.
Methods: Preclinical markers of vasculopathy in resistance vessels and conduit arteries and left ventricular structure and function were assessed in 39 obese subjects (BMI > 30 kg/m2) and 11 healthy weight controls. The influence of serum on cellular adhesion molecule (CAM) expression on human endothelial cells was studied ex vivo in a subgroup of 13 obese and nine healthy weight subjects. These analyses were repeated in all 17 of the obese subjects who complied with 4–9 months of lifestyle modification treatment (six with weight loss >5% and 11 with weight loss |
| doi_str_mv | 10.1111/j.1463-1326.2007.00817.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69629986</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20439276</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5017-330e789959b8d94b0b380027da35575ba014d8fcb92c95d3fd61af6a280958653</originalsourceid><addsrcrecordid>eNqNkUtv1DAUhS0EoqXwF5BX7BKu7fglsUEDFKQ-JChUYmM5jtPJkMdgO-3MvyeZjMoSvPG17nfulc9BCBPIyXTebnJSCJYRRkVOAWQOoIjMd0_Q6WPj6aGmmdJAT9CLGDcAUDAln6MTooAVquCnqLtZe-zr2rsU8VDjofSxSXts-wr3Q59t1zZ01g3tcNc42-IH39ytE26HOOE9vrfRja0NB_7e9yk0y7see5eaiZgbMYXRpTH4l-hZbdvoXx3vM_T908eb1efs4vr8y-r9ReY4EJkxBl4qrbkuVaWLEkqmAKisLONc8tICKSpVu1JTp3nF6koQWwtLFWiuBGdn6M0ydxuG36OPyXRNdL5tbe-HMRqhBdVaiX-CdHJMUzmDagFdmL4efG22oels2BsCZs7EbMxsvZmtN3Mm5pCJ2U3S18cdY9n56q_wGMIEvFuAh6b1-_8ebD5cX07FJM8WeROT3z3KbfhlhGSSm9urc_NNAvn6c3VrfrA_rJaqTA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20439276</pqid></control><display><type>article</type><title>The effects of obesity and non-pharmacological weight loss on vascular and ventricular function and structure</title><source>Wiley</source><creator>Skilton, M. R. ; Sieveking, D. P. ; Harmer, J. A. ; Franklin, J. ; Loughnan, G. ; Nakhla, S. ; Sullivan, D. R. ; Caterson, I. D. ; Celermajer, D. S.</creator><creatorcontrib>Skilton, M. R. ; Sieveking, D. P. ; Harmer, J. A. ; Franklin, J. ; Loughnan, G. ; Nakhla, S. ; Sullivan, D. R. ; Caterson, I. D. ; Celermajer, D. S.</creatorcontrib><description>Aims: The mechanisms by which obesity confers increased cardiovascular risk and the effects of moderate weight loss on cardiovascular health are incompletely understood. We sought to characterize the preclinical changes in cardiac and vascular health that accompany obesity and the influence of lifestyle modification on these parameters.
Methods: Preclinical markers of vasculopathy in resistance vessels and conduit arteries and left ventricular structure and function were assessed in 39 obese subjects (BMI > 30 kg/m2) and 11 healthy weight controls. The influence of serum on cellular adhesion molecule (CAM) expression on human endothelial cells was studied ex vivo in a subgroup of 13 obese and nine healthy weight subjects. These analyses were repeated in all 17 of the obese subjects who complied with 4–9 months of lifestyle modification treatment (six with weight loss >5% and 11 with weight loss <5%).
Results: Compared with healthy weight controls, obese subjects had decreased peak hyperaemic forearm blood flow (p = 0.015), increased carotid intima–media thickness (p = 0.009), increased left ventricular wall thickness and volume and evidence of systolic and diastolic dysfunction as assessed using tissue Doppler imaging (S′, p = 0.09; E′/A′, p = 0.02), and serum from obese subjects increased the intercellular CAM‐1 expression on human endothelial cells (p = 0.009). However, arterial endothelial function assessed by flow‐mediated dilatation was not altered (p = 0.99). Lifestyle modification treatment resulted in potentially beneficial changes in fibrinogen (p = 0.003), HDL cholesterol (p = 0.05) and soluble vascular CAM‐1 (p = 0.06). In subjects with weight loss greater than 5% of body weight, there was also a decrease in low‐level inflammation (high‐sensitivity C‐reactive protein, p = 0.05), lipid peroxidation (thiobarbituric acid–reactive substances, p = 0.05) and triglycerides (p = 0.07).
Conclusions: Obesity is associated with widespread alterations in cardiac and vascular structure and function. Moderate short‐term weight loss by lifestyle modification results in some beneficial changes in serum profile; however, these are not accompanied by significant alterations to either cardiac or vascular structure and function.</description><identifier>ISSN: 1462-8902</identifier><identifier>EISSN: 1463-1326</identifier><identifier>DOI: 10.1111/j.1463-1326.2007.00817.x</identifier><identifier>PMID: 18034845</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Biomarkers - blood ; cardiovascular disease ; Carotid Arteries - diagnostic imaging ; Case-Control Studies ; Chi-Square Distribution ; E-Selectin - blood ; Echocardiography ; endothelial function ; Exercise - physiology ; Female ; Humans ; Intercellular Adhesion Molecule-1 - blood ; Male ; obesity ; Obesity - blood ; Obesity - physiopathology ; Obesity - therapy ; Prospective Studies ; Regional Blood Flow - physiology ; Tunica Intima - diagnostic imaging ; Vascular Cell Adhesion Molecule-1 - blood ; Ventricular Dysfunction, Left - blood ; Ventricular Dysfunction, Left - diagnostic imaging ; ventricular function ; weight loss ; Weight Loss - physiology</subject><ispartof>Diabetes, obesity & metabolism, 2008-10, Vol.10 (10), p.874-884</ispartof><rights>2007 The Authors Journal Compilation © 2007 Blackwell Publishing Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5017-330e789959b8d94b0b380027da35575ba014d8fcb92c95d3fd61af6a280958653</citedby><cites>FETCH-LOGICAL-c5017-330e789959b8d94b0b380027da35575ba014d8fcb92c95d3fd61af6a280958653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18034845$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Skilton, M. R.</creatorcontrib><creatorcontrib>Sieveking, D. P.</creatorcontrib><creatorcontrib>Harmer, J. A.</creatorcontrib><creatorcontrib>Franklin, J.</creatorcontrib><creatorcontrib>Loughnan, G.</creatorcontrib><creatorcontrib>Nakhla, S.</creatorcontrib><creatorcontrib>Sullivan, D. R.</creatorcontrib><creatorcontrib>Caterson, I. D.</creatorcontrib><creatorcontrib>Celermajer, D. S.</creatorcontrib><title>The effects of obesity and non-pharmacological weight loss on vascular and ventricular function and structure</title><title>Diabetes, obesity & metabolism</title><addtitle>Diabetes Obes Metab</addtitle><description>Aims: The mechanisms by which obesity confers increased cardiovascular risk and the effects of moderate weight loss on cardiovascular health are incompletely understood. We sought to characterize the preclinical changes in cardiac and vascular health that accompany obesity and the influence of lifestyle modification on these parameters.
Methods: Preclinical markers of vasculopathy in resistance vessels and conduit arteries and left ventricular structure and function were assessed in 39 obese subjects (BMI > 30 kg/m2) and 11 healthy weight controls. The influence of serum on cellular adhesion molecule (CAM) expression on human endothelial cells was studied ex vivo in a subgroup of 13 obese and nine healthy weight subjects. These analyses were repeated in all 17 of the obese subjects who complied with 4–9 months of lifestyle modification treatment (six with weight loss >5% and 11 with weight loss <5%).
Results: Compared with healthy weight controls, obese subjects had decreased peak hyperaemic forearm blood flow (p = 0.015), increased carotid intima–media thickness (p = 0.009), increased left ventricular wall thickness and volume and evidence of systolic and diastolic dysfunction as assessed using tissue Doppler imaging (S′, p = 0.09; E′/A′, p = 0.02), and serum from obese subjects increased the intercellular CAM‐1 expression on human endothelial cells (p = 0.009). However, arterial endothelial function assessed by flow‐mediated dilatation was not altered (p = 0.99). Lifestyle modification treatment resulted in potentially beneficial changes in fibrinogen (p = 0.003), HDL cholesterol (p = 0.05) and soluble vascular CAM‐1 (p = 0.06). In subjects with weight loss greater than 5% of body weight, there was also a decrease in low‐level inflammation (high‐sensitivity C‐reactive protein, p = 0.05), lipid peroxidation (thiobarbituric acid–reactive substances, p = 0.05) and triglycerides (p = 0.07).
Conclusions: Obesity is associated with widespread alterations in cardiac and vascular structure and function. Moderate short‐term weight loss by lifestyle modification results in some beneficial changes in serum profile; however, these are not accompanied by significant alterations to either cardiac or vascular structure and function.</description><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>cardiovascular disease</subject><subject>Carotid Arteries - diagnostic imaging</subject><subject>Case-Control Studies</subject><subject>Chi-Square Distribution</subject><subject>E-Selectin - blood</subject><subject>Echocardiography</subject><subject>endothelial function</subject><subject>Exercise - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Intercellular Adhesion Molecule-1 - blood</subject><subject>Male</subject><subject>obesity</subject><subject>Obesity - blood</subject><subject>Obesity - physiopathology</subject><subject>Obesity - therapy</subject><subject>Prospective Studies</subject><subject>Regional Blood Flow - physiology</subject><subject>Tunica Intima - diagnostic imaging</subject><subject>Vascular Cell Adhesion Molecule-1 - blood</subject><subject>Ventricular Dysfunction, Left - blood</subject><subject>Ventricular Dysfunction, Left - diagnostic imaging</subject><subject>ventricular function</subject><subject>weight loss</subject><subject>Weight Loss - physiology</subject><issn>1462-8902</issn><issn>1463-1326</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqNkUtv1DAUhS0EoqXwF5BX7BKu7fglsUEDFKQ-JChUYmM5jtPJkMdgO-3MvyeZjMoSvPG17nfulc9BCBPIyXTebnJSCJYRRkVOAWQOoIjMd0_Q6WPj6aGmmdJAT9CLGDcAUDAln6MTooAVquCnqLtZe-zr2rsU8VDjofSxSXts-wr3Q59t1zZ01g3tcNc42-IH39ytE26HOOE9vrfRja0NB_7e9yk0y7see5eaiZgbMYXRpTH4l-hZbdvoXx3vM_T908eb1efs4vr8y-r9ReY4EJkxBl4qrbkuVaWLEkqmAKisLONc8tICKSpVu1JTp3nF6koQWwtLFWiuBGdn6M0ydxuG36OPyXRNdL5tbe-HMRqhBdVaiX-CdHJMUzmDagFdmL4efG22oels2BsCZs7EbMxsvZmtN3Mm5pCJ2U3S18cdY9n56q_wGMIEvFuAh6b1-_8ebD5cX07FJM8WeROT3z3KbfhlhGSSm9urc_NNAvn6c3VrfrA_rJaqTA</recordid><startdate>200810</startdate><enddate>200810</enddate><creator>Skilton, M. R.</creator><creator>Sieveking, D. P.</creator><creator>Harmer, J. A.</creator><creator>Franklin, J.</creator><creator>Loughnan, G.</creator><creator>Nakhla, S.</creator><creator>Sullivan, D. R.</creator><creator>Caterson, I. D.</creator><creator>Celermajer, D. S.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>200810</creationdate><title>The effects of obesity and non-pharmacological weight loss on vascular and ventricular function and structure</title><author>Skilton, M. R. ; Sieveking, D. P. ; Harmer, J. A. ; Franklin, J. ; Loughnan, G. ; Nakhla, S. ; Sullivan, D. R. ; Caterson, I. D. ; Celermajer, D. S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5017-330e789959b8d94b0b380027da35575ba014d8fcb92c95d3fd61af6a280958653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>cardiovascular disease</topic><topic>Carotid Arteries - diagnostic imaging</topic><topic>Case-Control Studies</topic><topic>Chi-Square Distribution</topic><topic>E-Selectin - blood</topic><topic>Echocardiography</topic><topic>endothelial function</topic><topic>Exercise - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Intercellular Adhesion Molecule-1 - blood</topic><topic>Male</topic><topic>obesity</topic><topic>Obesity - blood</topic><topic>Obesity - physiopathology</topic><topic>Obesity - therapy</topic><topic>Prospective Studies</topic><topic>Regional Blood Flow - physiology</topic><topic>Tunica Intima - diagnostic imaging</topic><topic>Vascular Cell Adhesion Molecule-1 - blood</topic><topic>Ventricular Dysfunction, Left - blood</topic><topic>Ventricular Dysfunction, Left - diagnostic imaging</topic><topic>ventricular function</topic><topic>weight loss</topic><topic>Weight Loss - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Skilton, M. R.</creatorcontrib><creatorcontrib>Sieveking, D. P.</creatorcontrib><creatorcontrib>Harmer, J. A.</creatorcontrib><creatorcontrib>Franklin, J.</creatorcontrib><creatorcontrib>Loughnan, G.</creatorcontrib><creatorcontrib>Nakhla, S.</creatorcontrib><creatorcontrib>Sullivan, D. R.</creatorcontrib><creatorcontrib>Caterson, I. D.</creatorcontrib><creatorcontrib>Celermajer, D. S.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes, obesity & metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Skilton, M. R.</au><au>Sieveking, D. P.</au><au>Harmer, J. A.</au><au>Franklin, J.</au><au>Loughnan, G.</au><au>Nakhla, S.</au><au>Sullivan, D. R.</au><au>Caterson, I. D.</au><au>Celermajer, D. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of obesity and non-pharmacological weight loss on vascular and ventricular function and structure</atitle><jtitle>Diabetes, obesity & metabolism</jtitle><addtitle>Diabetes Obes Metab</addtitle><date>2008-10</date><risdate>2008</risdate><volume>10</volume><issue>10</issue><spage>874</spage><epage>884</epage><pages>874-884</pages><issn>1462-8902</issn><eissn>1463-1326</eissn><abstract>Aims: The mechanisms by which obesity confers increased cardiovascular risk and the effects of moderate weight loss on cardiovascular health are incompletely understood. We sought to characterize the preclinical changes in cardiac and vascular health that accompany obesity and the influence of lifestyle modification on these parameters.
Methods: Preclinical markers of vasculopathy in resistance vessels and conduit arteries and left ventricular structure and function were assessed in 39 obese subjects (BMI > 30 kg/m2) and 11 healthy weight controls. The influence of serum on cellular adhesion molecule (CAM) expression on human endothelial cells was studied ex vivo in a subgroup of 13 obese and nine healthy weight subjects. These analyses were repeated in all 17 of the obese subjects who complied with 4–9 months of lifestyle modification treatment (six with weight loss >5% and 11 with weight loss <5%).
Results: Compared with healthy weight controls, obese subjects had decreased peak hyperaemic forearm blood flow (p = 0.015), increased carotid intima–media thickness (p = 0.009), increased left ventricular wall thickness and volume and evidence of systolic and diastolic dysfunction as assessed using tissue Doppler imaging (S′, p = 0.09; E′/A′, p = 0.02), and serum from obese subjects increased the intercellular CAM‐1 expression on human endothelial cells (p = 0.009). However, arterial endothelial function assessed by flow‐mediated dilatation was not altered (p = 0.99). Lifestyle modification treatment resulted in potentially beneficial changes in fibrinogen (p = 0.003), HDL cholesterol (p = 0.05) and soluble vascular CAM‐1 (p = 0.06). In subjects with weight loss greater than 5% of body weight, there was also a decrease in low‐level inflammation (high‐sensitivity C‐reactive protein, p = 0.05), lipid peroxidation (thiobarbituric acid–reactive substances, p = 0.05) and triglycerides (p = 0.07).
Conclusions: Obesity is associated with widespread alterations in cardiac and vascular structure and function. Moderate short‐term weight loss by lifestyle modification results in some beneficial changes in serum profile; however, these are not accompanied by significant alterations to either cardiac or vascular structure and function.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18034845</pmid><doi>10.1111/j.1463-1326.2007.00817.x</doi><tpages>11</tpages></addata></record> |
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| ispartof | Diabetes, obesity & metabolism, 2008-10, Vol.10 (10), p.874-884 |
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| source | Wiley |
| subjects | Adult Biomarkers - blood cardiovascular disease Carotid Arteries - diagnostic imaging Case-Control Studies Chi-Square Distribution E-Selectin - blood Echocardiography endothelial function Exercise - physiology Female Humans Intercellular Adhesion Molecule-1 - blood Male obesity Obesity - blood Obesity - physiopathology Obesity - therapy Prospective Studies Regional Blood Flow - physiology Tunica Intima - diagnostic imaging Vascular Cell Adhesion Molecule-1 - blood Ventricular Dysfunction, Left - blood Ventricular Dysfunction, Left - diagnostic imaging ventricular function weight loss Weight Loss - physiology |
| title | The effects of obesity and non-pharmacological weight loss on vascular and ventricular function and structure |
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