Maintenance of blood pressure control and left ventricular performance with small doses of enalapril

Enalapril treatment (20 mg every 12 hours) of 24 patients with essential hypertension and left ventricular (LV) hypertrophy established normal blood pressure (BP) after 8 weeks, and after 7 years had reduced LV mass index by 39% from 148 ± 34 to 90 ± 16 g/m 2, and had normalized LV structure and fun...

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Bibliographic Details
Published in:The American journal of cardiology 1999-03, Vol.83 (5), p.719-723
Main Authors: González-Juanatey, José Ramón, Reino, Antonio Pose, Garcı́a-Acuña, José Marı́a, González-Juanatey, Carlos, Valdes, Luis, de la Peña, Miguel Gil, Cabezas-Cerrato, José
Format: Article
Language:English
Subjects:
Adult
Angiotensin-Converting Enzyme Inhibitors - administration & dosage
Antihypertensive Agents - administration & dosage
Blood Pressure - drug effects
Cardiology
Drug therapy
Echocardiography
Electrocardiography - drug effects
Enalapril - administration & dosage
Exercise Test
Female
Follow-Up Studies
Heart
Heart Rate - drug effects
Heart Ventricles - diagnostic imaging
Heart Ventricles - drug effects
Humans
Hypertension
Hypertension - drug therapy
Hypertrophy, Left Ventricular - diagnostic imaging
Hypertrophy, Left Ventricular - drug therapy
Male
Middle Aged
Monitoring, Ambulatory
Pharmacology
Physical Exertion - physiology
Systole
Ventricular Function, Left - drug effects
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Summary:Enalapril treatment (20 mg every 12 hours) of 24 patients with essential hypertension and left ventricular (LV) hypertrophy established normal blood pressure (BP) after 8 weeks, and after 7 years had reduced LV mass index by 39% from 148 ± 34 to 90 ± 16 g/m 2, and had normalized LV structure and function and QT dispersion. Stepwise reduction of the enalapril dosage from 40 to 30, 20, 10, and 5 mg/day during the eighth year caused no significant changes in BP, LV structure, LV systolic function, or QT dispersion, which all likewise remained unaltered during a further year of the 5-mg/day regimen. We conclude that for hypertensive patients in whom prolonged treatment with standard doses of enalapril has normalized BP, LV structure and function, and QT dispersion, significantly smaller doses are sufficient to maintain these cardiovascular achievements.
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(98)00977-1