Drosophila SIN3 is required at multiple stages of development

SIN3 is a component of a histone deacetylase complex known to be important for transcription repression. While multiple isoforms of SIN3 have been reported, little is known about their relative expression or role in development. Using a combination of techniques, we have determined that SIN3 is expr...

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Bibliographic Details
Published in:Developmental dynamics 2008-10, Vol.237 (10), p.3040-3050
Main Authors: Sharma, Vishal, Swaminathan, Aishwarya, Bao, Riyue, Pile, Lori A.
Format: Article
Language:English
Subjects:
Alternative Splicing - genetics
Animals
Body Patterning
deacetylation
Drosophila
Drosophila melanogaster - embryology
Drosophila melanogaster - genetics
Drosophila melanogaster - growth & development
Drosophila melanogaster - metabolism
Female
Gene Expression Regulation, Developmental
Male
Mutation - genetics
Repressor Proteins - genetics
Repressor Proteins - metabolism
SIN3
transcription
Transcription, Genetic - genetics
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Summary:SIN3 is a component of a histone deacetylase complex known to be important for transcription repression. While multiple isoforms of SIN3 have been reported, little is known about their relative expression or role in development. Using a combination of techniques, we have determined that SIN3 is expressed throughout the Drosophila life cycle. The pattern of expression for each individual isoform, however, is distinct. Knock down of all SIN3 expression reveals a requirement for this protein in embryonic and larval periods. Taken together, the data suggest that SIN3 is required for multiple developmental events during the Drosophila life cycle. Developmental Dynamics 237:3040–3050, 2008. © 2008 Wiley‐Liss, Inc.
ISSN:1058-8388
1097-0177
DOI:10.1002/dvdy.21706