Diastolic Compliance Is Reduced in Obese Rabbits

Obesity often leads to symptoms of cardiopulmonary congestion associated with normal systolic but abnormal diastolic function. This study analyzed alterations in passive diastolic compliance in obesity using the rabbit model. New Zealand White rabbits were fed a normal (n=8) or 10% added fat diet (n...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1999-03, Vol.33 (3), p.811-815
Main Authors: Carroll, Joan F, Summers, Richard L, Dzielak, David J, Cockrell, Kathy, Montani, Jean-Pierre, Mizelle, H. Leland
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Pressure - physiology
Compliance
Computer Simulation
Coronary Circulation
Disease Models, Animal
Female
Heart - physiopathology
Heart Rate
Medical sciences
Metabolic diseases
Obesity
Obesity - physiopathology
Physical Conditioning, Animal
Rabbits
Rest
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Summary:Obesity often leads to symptoms of cardiopulmonary congestion associated with normal systolic but abnormal diastolic function. This study analyzed alterations in passive diastolic compliance in obesity using the rabbit model. New Zealand White rabbits were fed a normal (n=8) or 10% added fat diet (n=8). After 12 weeks, rabbits fed the high fat diet developed obesity (5.34 +/- 0.11 versus 3.68 +/- 0.04 kg, P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.33.3.811