Application of transcervical hysterofetoscopy and cord blood collection at first trimester termination of pregnancy for fetal abnormalities

• Published in: Prenatal diagnosis 2008-10, Vol.28 (10), p.939-942
• Main Authors: Chan, B. C., Hui, P. W., Leung, W. C., Leung, K. Y., Pun, T. C., Lee, C. P.
• Format: Article
• Language: English
• Subjects: Abortion, Induced; Biological and medical sciences; Blood Specimen Collection - methods; Chromosome Aberrations; Delivery. Postpartum. Lactation; Female; Fetal Blood; fetal cord blood collection; Fetoscopy - methods; Fetus - abnormalities; first trimester gestation; Fundamental and applied biological sciences. Psychology; Genetics of eukaryotes. Biological and molecular evolution; Gestational Age; Gynecology. Andrology. Obstetrics; Humans; Hysteroscopy - methods; Lymphangioma, Cystic - diagnosis; Lymphangioma, Cystic - embryology; Medical sciences; mesenchymal stem cells; Molecular and cellular biology; Pregnancy; Pregnancy Trimester, First; Prenatal Diagnosis - methods; transcervical hysterofetoscopy; Ultrasonography, Prenatal
• ISSN: 0197-3851; 1097-0223
• DOI: 10.1002/pd.2085

Objective To examine the applicability of hysterofetoscopy and cord blood collection at first trimester termination of pregnancy for fetal abnormalities. Methods From 2004 to 2007, transcervical hysterofetoscopy was performed in seven patients at the same operation setting of surgical termination of pregnancy. The findings were compared with prenatal diagnosis. Feasibility of cord blood collection was also examined. Results Out of these seven patients, six of them had prenatal ultrasound diagnosis of cystic hygroma. All of them had chromosomal abnormalities. Subcutaneous oedema was confirmed by hysterofetoscopy with good view. Another pregnancy was complicated by homozygous alpha thalassaemia and the diagnosis was confirmed by electrophoresis of fetal haemoglobin collected from umbilical cord vessel. Cord blood collection was also attempted in two other patients yielding fetal blood with minimal maternal contamination. Conclusion Transcervical hysterofetoscopy is a feasible tool in confirming external fetal structural abnormalities before surgical termination of pregnancy. It can be performed under either general anaesthesia or conscious sedation. Umbilical cord blood collection can facilitate confirmation of genetic diseases. It may also allow the potential of isolating fetal mesenchymal stem cell in first trimester. Copyright © 2008 John Wiley & Sons, Ltd.