Breath analysis in patients with end-stage renal disease: effect of haemodialysis

ABSTRACT Background  There is no agreement about exhaled nitric oxide (FENO) and its change after haemodialysis (HD) in end‐stage renal disease (ESRD) patients. To comprehensively assess NO production in the respiratory system, NO metabolites in exhaled breath condensate (EBC) needs to be measured i...

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Bibliographic Details
Published in:European journal of clinical investigation 2008-10, Vol.38 (10), p.728-733
Main Authors: Rolla, G., Bruno, M., Bommarito, L., Heffler, E., Ferrero, N., Petrarulo, M., Bagnis, C., Bugiani, M., Guida, G.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Airway ammonia
airway pH
Ammonia - analysis
Biological and medical sciences
Biomarkers - analysis
Breath Tests
Case-Control Studies
end-stage renal disease
exhaled breath condensate
exhaled nitric oxide
Female
General aspects
haemodialysis
Humans
Hydrogen-Ion Concentration
Kidney Failure, Chronic - metabolism
Kidney Failure, Chronic - therapy
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Nitrates - analysis
Nitric Oxide - analysis
Nitrites - analysis
Nitrogen Dioxide - analysis
Renal Dialysis
Renal failure
Statistics, Nonparametric
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Summary:ABSTRACT Background  There is no agreement about exhaled nitric oxide (FENO) and its change after haemodialysis (HD) in end‐stage renal disease (ESRD) patients. To comprehensively assess NO production in the respiratory system, NO metabolites in exhaled breath condensate (EBC) needs to be measured in addition to FENO, taking into account the influence on these markers of airway pH, which may be regulated by ammonia (), present in large amounts in the breath of ESRD patients and removed by HD. Study design  FENO and NO metabolites (NOx, , ), pH and in EBC were measured in 12 ESRD patients, before and after HD. Twelve healthy subjects acted as controls. Results  FENO values of ESRD patients were similar to normals, while EBC‐NOx, , and pH were significantly higher in ESRD patients compared to normals (EBC‐NOx 12·3, range 11·1–41·9 µm vs. 9·4, range 4·6–10·9 µm, P = 0·007; 4·70, range 1·17–8·22 µm vs. 0·90, range 0·72–1·17 µm, P = 0·023; 2340, range 1325–3922 µm vs. 660, range 406–872 µm, P 
ISSN:0014-2972
1365-2362
DOI:10.1111/j.1365-2362.2008.02016.x