Effect of Hypoxia on Circulating Levels of Retina-Specific Messenger RNA in Type 2 Diabetes Mellitus

Previously it was shown that the circulating rhodopsin mRNA level was higher in diabetic retinopathy (DR). Recent evidence suggests that hypoxia may also be associated with DR. The aim of this study was to investigate the effect of oxygen desaturation on circulating retina‐specific mRNA in type 2 di...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2008-08, Vol.1137 (1), p.243-252
Main Authors: Wong, Amy, Merritt, Simon, Butt, Asif N., Williams, Adrian, Swaminathan, R.
Format: Article
Language:English
Subjects:
Aged
Biomarkers - blood
Carrier Proteins - genetics
Carrier Proteins - metabolism
cis-trans-Isomerases
diabetes mellitus
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - genetics
Diabetes Mellitus, Type 2 - pathology
Diabetic Retinopathy - blood
Diabetic Retinopathy - diagnosis
Diabetic Retinopathy - genetics
Diabetic Retinopathy - pathology
Eye Proteins - genetics
Eye Proteins - metabolism
Female
Gene Expression Regulation
Humans
Hypoxia
Male
Middle Aged
obstructive sleep apnea
Oximetry
Oxygen - metabolism
Retina - chemistry
Retina - pathology
Retina - physiology
retinopathy
rhodopsin
Rhodopsin - genetics
Rhodopsin - metabolism
RNA, Messenger - blood
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Summary:Previously it was shown that the circulating rhodopsin mRNA level was higher in diabetic retinopathy (DR). Recent evidence suggests that hypoxia may also be associated with DR. The aim of this study was to investigate the effect of oxygen desaturation on circulating retina‐specific mRNA in type 2 diabetic patients. Thirty‐five type 2 diabetic patients underwent overnight oximetry. Two parameters from oximetry were used to measure oxygen desaturation: the number of times per hour the oxygen saturation decreased by 4% or greater (number of dips/hr) and percentage of sleep time with oxygen saturation (SpO2)
ISSN:0077-8923
1749-6632
1930-6547
DOI:10.1196/annals.1448.001