Serial effects of high-resistance and prolonged endurance training on Na+-K+ pump concentration and enzymatic activities in human vastus lateralis

• Published in: Acta physiologica Scandinavica 1999-02, Vol.165 (2), p.177-184
• Main Authors: Green, H, Dahly, A, Shoemaker, K, Goreham, C, Bombardier, E, Ball-Burnett, M
• Format: Article
• Language: English
• Subjects: 3-Hydroxyacyl CoA Dehydrogenases - metabolism; Adult; aerobic power; Biological and medical sciences; Biopsy; Energy Metabolism - physiology; Follow-Up Studies; Fundamental and applied biological sciences. Psychology; Hexokinase - metabolism; Humans; Malate Dehydrogenase - metabolism; metabolic pathways; Mitochondria, Muscle - enzymology; muscle; Muscle, Skeletal - cytology; Muscle, Skeletal - enzymology; Na+-K+ ATPase; Phosphofructokinase-1 - metabolism; Phosphorylases - metabolism; Physical Endurance - physiology; Sodium-Potassium-Exchanging ATPase - biosynthesis; Space life sciences; Striated muscle. Tendons; training; Vertebrates: osteoarticular system, musculoskeletal system
• ISSN: 0001-6772; 1365-201X
• DOI: 10.1046/j.1365-201x.1999.00484.x

The purpose of this study was to compare two contrasting training models, namely high‐resistance training and prolonged submaximal training on the expression of Na+–K+ ATPase and changes in the potential of pathways involved in energy production in human vastus lateralis. The high‐resistance training group (VO2peak = 45.3 ± 1.9 mL kg−1 min−1, mean ± SE, n = 9) performed three sets of six to eight repetitions maximal, each of squats, leg presses and leg extensions, three times per week for 12 weeks, while the prolonged submaximal training group (VO2peak = 44.4 ± 6.6  mL kg−1 min−1, n = 7) cycled 5–6 times per week for 2 h day−1 at 68% VO2peak for 11 weeks. In the HRT group, Na+–K+ ATPase (pmol g−1 wet wt), measured with the 3H‐ouabain binding technique, showed no change from 0 (289 ± 22) to 4 weeks (283 ± 15), increased (P