Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis

Furin is a secretory pathway endoprotease that catalyses the maturation of a strikingly diverse group of proprotein substrates, ranging from growth factors and receptors to pathogen proteins, in multiple compartments within the trans-Golgi network (TGN)/endosomal system. This review focuses on recen...

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Published in:Trends in cell biology 1999-01, Vol.9 (1), p.28-35
Main Authors: Molloy, S S, Anderson, E D, Jean, F, Thomas, G
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Binding Sites
endoproteinase
Extracellular Matrix - metabolism
Furin
Golgi Apparatus - metabolism
Hydrogen-Ion Concentration
Molecular Sequence Data
Subtilisins - metabolism
Virulence
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description Furin is a secretory pathway endoprotease that catalyses the maturation of a strikingly diverse group of proprotein substrates, ranging from growth factors and receptors to pathogen proteins, in multiple compartments within the trans-Golgi network (TGN)/endosomal system. This review focuses on recent developments in the biochemistry and cell biology of the endoprotease, including the mechanism of TGN localization, phosphorylation-dependent regulation of protein traffic, and novel insights into early embryogenesis, extracellular matrix formation and pathogen virulence.
doi_str_mv 10.1016/s0962-8924(98)01382-8
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subjects Amino Acid Sequence
Animals
Binding Sites
endoproteinase
Extracellular Matrix - metabolism
Furin
Golgi Apparatus - metabolism
Hydrogen-Ion Concentration
Molecular Sequence Data
Subtilisins - metabolism
Virulence
title Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis
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