The Controversial M Cell

The Controversial M Cell. A recent publication by us bas been interpreted by some as arguing against the existence and importance of M cells. We suppose this is the reason we have been asked to write this “controversy.” Regrettably for the controversy, neither our work nor we deny the existence of M...

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Published in:Journal of cardiovascular electrophysiology 1999-02, Vol.10 (2), p.244-260
Main Authors: ANYUKHOVSKY, EVGENY P., SOSUNOV, EUGENE A., GAINULLIN, RAVIL Z., ROSEN, MICHAEL R.
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Action Potentials - physiology
activation-recovers intervals
Animals
Anti-Arrhythmia Agents - pharmacology
cardiac electrophysiology
Endocardium - cytology
Endocardium - drug effects
Endocardium - physiology
Heart Ventricles - cytology
Heart Ventricles - drug effects
Humans
Membrane Potentials
Myocardium - cytology
Myocardium - metabolism
Neurotransmitter Agents - pharmacology
Pericardium - cytology
Pericardium - drug effects
Pericardium - physiology
transmural gradients
ventricular action potentials
ventricular electrograms
Ventricular Function
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Summary:The Controversial M Cell. A recent publication by us bas been interpreted by some as arguing against the existence and importance of M cells. We suppose this is the reason we have been asked to write this “controversy.” Regrettably for the controversy, neither our work nor we deny the existence of M cells. Rather, we have confirmed, conceivably ad nauseum, that M cells do exist and contribute importantly to the expression of electrical activity in the intact myocardium. What controversy there is relates to (1) whether there is an inhomogeneous transmural gradient for ventricular repolarization in normal hearts, and (2) why the electrophysiologic properties of different myocardial sites differ so markedly at the level of the isolated tissue and single cell and yet become so much more homogenous in the intact ventricle. These issues are addressed on the following pages.
ISSN:1045-3873
1540-8167
DOI:10.1111/j.1540-8167.1999.tb00667.x