Topiramate for intractable childhood epilepsy

To better define the efficacy and tolerability of the new anticonvulsant topiramate in pediatric patients, the clinical courses of 49 children with intractable seizures were monitored during topiramate therapy. The 80% of children who had complex partial seizures experienced better seizure control w...

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Bibliographic Details
Published in:Seizure (London, England) England), 1999-02, Vol.8 (1), p.38-40
Main Authors: Moreland, E.C., Griesemer, D.A., Holden, K.R.
Format: Article
Language:English
Subjects:
Adult
Anticonvulsants - therapeutic use
antiepileptic drug
Child
Child, Preschool
children
Dose-Response Relationship, Drug
epilepsy
Epilepsy - drug therapy
Female
Fructose - adverse effects
Fructose - analogs & derivatives
Humans
Infant
Male
topiramate
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Summary:To better define the efficacy and tolerability of the new anticonvulsant topiramate in pediatric patients, the clinical courses of 49 children with intractable seizures were monitored during topiramate therapy. The 80% of children who had complex partial seizures experienced better seizure control with topiramate than the 20% who had generalized seizures. Efficacy was greatest with doses between 2.5 and 7.5 mg/kg/day. More than half the children on topiramate experienced adverse effects which could interfere with learning at school, but 20% demonstrated increased alertness or improved behavior. Topiramate is effective and may be considered as part of the treatment pathway for complex partial seizures in children, although careful monitoring of cognitive function is required.
ISSN:1059-1311
1532-2688
DOI:10.1053/seiz.1998.0212