Type I (insulin-dependent) diabetes mellitus and cow milk : casein variant consumption

Previously published Type I (insulin-dependent) diabetes mellitus incidence in 0 to 14-year-old children from 10 countries or areas was compared with the national annual cow milk protein consumption. Countries which were selected for study had appropriate milk protein polymorphism studies, herd bree...

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Bibliographic Details
Published in:Diabetologia 1999-03, Vol.42 (3), p.292-296
Main Authors: ELLIOTT, R. B, HARRIS, D. P, HILL, J. P, BIBBY, N. J, WASMUTH, H. E
Format: Article
Language:English
Subjects:
Adolescent
Amino Acid Sequence
Animals
Biological and medical sciences
Canada - epidemiology
Caseins - adverse effects
Caseins - chemistry
Caseins - genetics
Cattle
Child
Child, Preschool
Diabetes Mellitus, Type 1 - epidemiology
Diabetes Mellitus, Type 1 - etiology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Endorphins - chemistry
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Europe - epidemiology
Female
Genetic Variation
Humans
Incidence
Infant
Medical sciences
Milk - adverse effects
Milk - chemistry
Milk Proteins
New Zealand - epidemiology
Peptide Fragments - chemistry
United States - epidemiology
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Summary:Previously published Type I (insulin-dependent) diabetes mellitus incidence in 0 to 14-year-old children from 10 countries or areas was compared with the national annual cow milk protein consumption. Countries which were selected for study had appropriate milk protein polymorphism studies, herd breed composition information and low dairy imports from other countries. Total protein consumption did not correlate with diabetes incidence (r = +0.402), but consumption of the beta-casein A1 variant did (r = +0.726). Even more pronounced was the relation between beta-casein (A1+B) consumption and diabetes (r = +0.982). These latter two cow caseins yield a bioactive peptide beta-casomorphin-7 after in vitro digestion with intestinal enzymes whereas the common A2 variant or the corresponding human or goat caseins do not. beta-casomorphin-7 has opioid properties including immunosuppression, which could account for the specificity of the relation between the consumption of some but not all beta-casein variants and diabetes incidence.
ISSN:0012-186X
1432-0428
DOI:10.1007/s001250051153