Visceral leishmaniasis after renal transplantation: report of 4 cases in northeastern Brazil

: Visceral leishmaniasis (VL) is a well recognized opportunistic infection in immunosuppressed patients, which may cause febrile illness. We describe 4 renal transplant patients with VL in an endemic area in Brazil and their response to therapy. In 3 cases the diagnosis was confirmed by bone marrow...

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Bibliographic Details
Published in:Transplant infectious disease 2008-10, Vol.10 (5), p.364-368
Main Authors: Oliveira, R.A., Silva, L.S.V., Carvalho, V.P., Coutinho, A.F., Pinheiro, F.G., Lima, C.G., Leandro Júnior, J.E., Silva Júnior, G.B., Daher, E.F.
Format: Article
Language:English
Subjects:
Adult
Amphotericin B - therapeutic use
Animals
Antiprotozoal Agents - therapeutic use
Biopsy, Needle
Bone Marrow - parasitology
Bone Marrow - pathology
Brazil
Diagnosis, Differential
Female
Humans
immunosuppression
Kidney Failure, Chronic - surgery
Kidney Transplantation - adverse effects
Leishmania
Leishmaniasis, Visceral - diagnosis
Leishmaniasis, Visceral - drug therapy
Leishmaniasis, Visceral - etiology
Leishmaniasis, Visceral - pathology
Lima
Male
Middle Aged
renal transplantation
Spleen - parasitology
Spleen - pathology
Transplantation Conditioning - adverse effects
visceral leishmaniasis
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Summary:: Visceral leishmaniasis (VL) is a well recognized opportunistic infection in immunosuppressed patients, which may cause febrile illness. We describe 4 renal transplant patients with VL in an endemic area in Brazil and their response to therapy. In 3 cases the diagnosis was confirmed by bone marrow aspirate that revealed the presence of Leishmania. In 1 case the bone marrow aspirate was inconclusive and the diagnosis was made through spleen biopsy that showed the presence of the parasite. VL needs to be considered as a cause of febrile illness in transplanted patients living in endemic areas.
ISSN:1398-2273
1399-3062
DOI:10.1111/j.1399-3062.2008.00320.x