Semi-automated measurement of hyperdense, hypodense and heterogeneous hepatic metastasis on standard MDCT slices. Comparison of semi-automated and manual measurement of RECIST and WHO criteria

• Published in: European radiology 2008-11, Vol.18 (11), p.2456-2465
• Main Authors: Keil, Sebastian, Behrendt, Florian F., Stanzel, Sven, Sühling, Michael, Koch, Alexander, Bubenzer, Jhenee, Mühlenbruch, Georg, Mahnken, Andreas H., Günther, Rolf W., Das, Marco
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Algorithms; Artificial Intelligence; Carcinoma, Hepatocellular - diagnostic imaging; Carcinoma, Hepatocellular - secondary; Computer Applications; Diagnostic Radiology; Humans; Imaging; Internal Medicine; Interventional Radiology; Liver Neoplasms - diagnostic imaging; Medicine; Medicine & Public Health; Middle Aged; Neuroradiology; Pattern Recognition, Automated - methods; Radiographic Image Enhancement - methods; Radiographic Image Interpretation, Computer-Assisted - methods; Radiology; Reproducibility of Results; Sensitivity and Specificity; Tomography, X-Ray Computed - methods; Ultrasound; World Health Organization
• ISSN: 0938-7994; 1432-1084
• DOI: 10.1007/s00330-008-1050-6

As semi-automated measurement would be desirable for lesion quantification and therapy-response control, the purpose of this study was to compare semi-automated measurements with manual assessment of different types of hepatic metastases. Seventy-six patients with known liver metastases were analysed. All of them underwent contrast-enhanced 16-MDCT (16 × 0.75 mm collimation, 120 kV, 0.5 s rotation time, 160 mAs eff ) for evaluation of follow-up status. On the basis of standard reconstructed 5-mm slices (in 4-mm increments), each lesion was quantified based on RECIST and WHO criteria using a semi-automated software tool (Syngo Oncology) and also manually by an experienced radiologist. Results from the software were compared to manual measurements. Statistical analysis was performed applying the concordance correlation coefficient, and results were represented graphically in Bland-Altman plots. A total of 52 hyperdense, 57 hypodense and 56 heterogeneous metastases were found and correctly measured by the software. All three lesion types revealed a strong correlation agreement between measurement techniques [RECIST diameter: 0.93 (hyperdense), 0.95(hypodense), 0.94 (heterogeneous); WHO area: 0.95, 0.98, 0.93]. Semi-automatic measurement of hyperdense, hypodense and heterogeneous liver metastases showed reliable results on standard axial reconstructions in comparison to manual quantification.