Sickle cell‐like crisis and bone marrow necrosis associated with parvovirus B19 infection and heterozygosity for haemoglobins S and E

. In the literature, heterozygosity for haemoglobins S and E is known as a clinically benign condition. Nevertheless, we present a case of double heterozygosity manifesting as an infarctive sickle cell‐like crisis with acute chest syndrome and reversible bone marrow necrosis. Importantly, these comp...

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Bibliographic Details
Published in:Journal of internal medicine 1999-01, Vol.245 (1), p.103-106
Main Authors: Eichhorn, R. F., Buurke, E. J., Blok, P., Berends, M. J. H., Jansen, C. L.
Format: Article
Language:English
Subjects:
Adult
Anemia, Sickle Cell - etiology
Anemia, Sickle Cell - genetics
Anemia, Sickle Cell - virology
Anemias. Hemoglobinopathies
Biological and medical sciences
Bone Marrow - pathology
Bone Marrow - virology
Diseases of red blood cells
Female
haemoglobinopathy
Hematologic and hematopoietic diseases
Hemoglobin E - genetics
Hemoglobin, Sickle - genetics
Heterozygote
Humans
marrow necrosis
Medical sciences
Necrosis
Parvoviridae Infections - complications
parvovirus
Parvovirus B19, Human
sickle cell
Tropical medicine
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Summary:. In the literature, heterozygosity for haemoglobins S and E is known as a clinically benign condition. Nevertheless, we present a case of double heterozygosity manifesting as an infarctive sickle cell‐like crisis with acute chest syndrome and reversible bone marrow necrosis. Importantly, these complications were associated with serologically documented parvovirus B19 infection. Reviewing the literature, this case emphasizes a specific role of parvovirus B19 as a precipitating cause. Furthermore, it demonstrates how important the consideration of haemoglobin disorders can be even outside of the historically known areas.
ISSN:0954-6820
1365-2796
DOI:10.1046/j.1365-2796.1999.0445f.x