The use of fluconazole as a local irrigant for nephrostomy tubes

Few data exist concerning the combined use of fluconazole systemically and as an irrigant for nephrostomy tubes in a patient with renal candidiasis. The patient described here presented with renal fungal balls obstructing the drainage of urine from her nephrostomy tubes. Twelve months after chemorad...

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Bibliographic Details
Published in:Military medicine 1999-03, Vol.164 (3), p.239-241
Main Authors: CLARK, M. A, GAUNT, T, CZACHOR, J. S
Format: Article
Language:English
Subjects:
Adult
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - therapeutic use
Biological and medical sciences
Candidiasis - drug therapy
Candidiasis - etiology
Carcinoma, Squamous Cell - drug therapy
Catheters
Cervix
Chemotherapy
Creatinine
Fatal Outcome
Female
Fluconazole - therapeutic use
Fungal infections
Fungemia - drug therapy
Fungemia - etiology
Humans
Kidney Diseases - drug therapy
Kidney Diseases - etiology
Medical sciences
Nephrostomy, Percutaneous
Patients
Pharmacology. Drug treatments
Silicones
Stents
Therapeutic Irrigation - methods
Uremia
Urine
Urogenital system
Uterine Cervical Neoplasms - drug therapy
Vagina
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Summary:Few data exist concerning the combined use of fluconazole systemically and as an irrigant for nephrostomy tubes in a patient with renal candidiasis. The patient described here presented with renal fungal balls obstructing the drainage of urine from her nephrostomy tubes. Twelve months after chemoradiation for a stage IIB squamous cell carcinoma of the uterine cervix, a 35-year-old woman presented with renal obstruction necessitating insertion of ureteral stents. After 6 months of chemotherapy, the patient developed uremia. After nephrostomy tubes were placed, renal candidiasis was noted, and fluconazole was begun systemically. When the renal candidiasis failed to clear, nephrostomy tube irrigations were begun. Fourteen days of therapy with fluconazole resulted in the resolution of the uremia. The patient died 6 months later with her nephrostomy tubes in situ and without evidence of candidiasis in her urinary tract. The patient described was successfully treated without having to remove her nephrostomy tubes. Two other authors have reported the successful use of fluconazole irrigation to treat candidiasis in nephrostomy tubes that was unresponsive to systemic fluconazole. Before the appearance of these reports, the best results were obtained with removal of the catheter in renal candidiasis.
ISSN:0026-4075
1930-613X
DOI:10.1093/milmed/164.3.239