Altered pharmacology in the intensive care unit patient

Critically ill patients, not infrequently present alterations of physiological parameters that determine the success/failure of therapeutic interventions as well as the final outcome. Sepsis and polytrauma are two of the most common and complex syndromes occurring in Intensive Care Unit (ICU) and af...

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Bibliographic Details
Published in:Fundamental & clinical pharmacology 2008-10, Vol.22 (5), p.493-501
Main Authors: Zagli, Giovanni, Tarantini, Francesca, Bonizzoli, Manuela, Di Filippo, Alessandro, Peris, Adriano, De Gaudio, Angelo Raffaele, Geppetti, Pierangelo
Format: Article
Language:English
Subjects:
Biological and medical sciences
Critical Illness - mortality
Critical Illness - therapy
Hospital Mortality - trends
Humans
intensive care unit
Intensive Care Units - trends
Medical sciences
Multiple Trauma - drug therapy
Multiple Trauma - metabolism
Multiple Trauma - mortality
Pharmaceutical Preparations - administration & dosage
Pharmaceutical Preparations - metabolism
pharmacokinetic
pharmacology
Pharmacology. Drug treatments
sepsis
Sepsis - drug therapy
Sepsis - metabolism
Sepsis - mortality
trauma
Treatment Outcome
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Summary:Critically ill patients, not infrequently present alterations of physiological parameters that determine the success/failure of therapeutic interventions as well as the final outcome. Sepsis and polytrauma are two of the most common and complex syndromes occurring in Intensive Care Unit (ICU) and affect drug absorption, disposition, metabolism and elimination. Pharmacological management of ICU patients requires consideration of the unique pharmacokinetics associated with these clinical conditions and the likely occurrence of drug interaction. Rational adjustment in drug choice and dosing contributes to the appropriateness of treatment of those patients.
ISSN:0767-3981
1472-8206
DOI:10.1111/j.1472-8206.2008.00623.x