Histology and Tissue Chemistry of Tidemark Separation in Hamsters

Adult articular cartilage is divided by the tidemark into a deep calcified layer and a more superficial uncalcified layer. Histologic examination of articular cartilage from the knee joint of golden Syrian hamsters 123 days of age or older revealed defects at the tidemark in the tibia. Defects range...

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Bibliographic Details
Published in:Veterinary pathology 1999-03, Vol.36 (2), p.138-145
Main Authors: Otterness, I. G., Chang, M., Burkhardt, J. E., Sweeney, F. J., Milici, A. J.
Format: Article
Language:English
Subjects:
Age Factors
Animals
Calcinosis - pathology
Calcinosis - veterinary
Cartilage, Articular - pathology
Cartilage, Articular - physiology
Chromatography, Liquid - veterinary
Collagen - chemistry
Cricetinae
Eosine Yellowish-(YS) - chemistry
Female
Hematoxylin - chemistry
Hindlimb
Hydroxyproline - chemistry
Indicators and Reagents - chemistry
Joints - pathology
Mesocricetus - anatomy & histology
Mesocricetus - physiology
Osteoarthritis - pathology
Osteoarthritis - veterinary
Phenazines - chemistry
Physical Conditioning, Animal
Rodent Diseases - pathology
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Summary:Adult articular cartilage is divided by the tidemark into a deep calcified layer and a more superficial uncalcified layer. Histologic examination of articular cartilage from the knee joint of golden Syrian hamsters 123 days of age or older revealed defects at the tidemark in the tibia. Defects ranged from small separations of the calcified and uncalcified layers along the tidemark to progressively larger defects apparently formed by dissolution. These larger defects appeared as cavities in the noncalcified cartilage, had smooth rather than rough edges, frequently contained coalesced debris, and often resulted in a bulge in the articular surface. Occasionally, these large defects broke through the articular surface. Defects were not observed in tibial cartilage of younger (
ISSN:0300-9858
1544-2217
DOI:10.1354/vp.36-2-138