Serum Cardiac Troponin I Concentration in Dogs with Ehrlichiosis

• Published in: Journal of veterinary internal medicine 2008-09, Vol.22 (5), p.1136-1143
• Main Authors: Diniz, P.P.V.P, Morais, H.S.A. de, Breitschwerdt, E.B, Schwartz, D.S
• Format: Article
• Language: English
• Subjects: Anaplasma; Animals; Babesia canis; Bartonella; Biomarkers - blood; Borrelia burgdorferi; Canine monocytic ehrlichiosis; Dirofilaria immitis; Dog Diseases - blood; Dogs; Ehrlichia canis; Ehrlichia chaffeensis; Ehrlichia ewingii; ehrlichiosis; Ehrlichiosis - blood; Ehrlichiosis - veterinary; Female; heart diseases; Heart Diseases - blood; Heart Diseases - complications; Heart Diseases - veterinary; Male; Myocarditis; Odds Ratio; Rickettsia; Risk factor; Risk Factors; SIRS; Troponin; Troponin I - blood; troponins
• ISSN: 0891-6640; 1939-1676
• DOI: 10.1111/j.1939-1676.2008.0145.x

Background: Ehrlichiosis is a multisystemic disease with the potential to cause cardiomyocyte injury in naturally infected dogs. Hypothesis: Myocardial injury occurs in dogs infected with Ehrlichia canis. Animals: One‐hundred and ninety‐four dogs from Brazil with clinical and laboratory abnormalities indicative of ehrlichiosis. Sixteen healthy dogs served as controls. Methods: Electrocardiogram, echocardiogram, noninvasive blood pressure measurement, and serum cardiac troponin I (cTnI) concentrations were evaluated. Serologic assays and PCR determined the exposure and infection status for E. canis, Anaplasma spp., Babesia canis vogeli, Bartonella spp., Borrelia burgdorferi, Dirofilaria immitis, Ehrlichia chaffeensis, Ehrlichia ewingii, Leishmania chagasi, and spotted‐fever group Rickettsia. Dogs were assigned to groups according to PCR status: E. canis infected, infected with other vector‐borne organisms, sick dogs lacking PCR evidence for infection, and healthy controls. Results: E. canis‐infected dogs had higher serum cTnI concentrations than controls (median: 0.04 ng/dL; range 0.04–9.12 ng/dL; control median: 0.04 ng/dL; range: 0.04–0.10 ng/dL; P= .012), and acute E. canis infection was associated with myocardial injury (odds ratio [OR]: 2.67, confidence interval [CI] 95%: 1.12–6.40, P= .027). Severity of anemia was correlated with increased risk of cardiomyocyte damage (r= 0.84, P < .001). Dogs with clinical signs of systemic inflammatory response syndrome (SIRS) were at higher risk for myocardial injury than were other sick dogs (OR: 2.55, CI 95%: 1.31–4.95, P= .005). Conclusions and Clinical Importance: Acute infection with E. canis is a risk factor for myocardial injury in naturally infected Brazilian dogs. Severity of anemia and SIRS might contribute to the pathophysiology of myocardial damage.