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Synthesis, characterization, and biodistribution of oxo complexes of technetium-99m with biguanide and N1-Substituted ligands
We report the synthesis, characterization, and biodistribution of 99mTc-complexes with the bidentate- N,N chelate biguanide (Big) and the N1- substituted ligands dimethyl (DMBig), phenyl (PBig), and phenethyl (PEBig). Dynamic gamma-camera studies with 99mTc-Big and 99mTc-DMSA in rabbits indicated di...
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| Published in: | Nuclear medicine and biology 1999, Vol.26 (1), p.79-83 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c390t-b03ce728db3ee66047eb9995ea91ee7e46f24ab41535796f14b2527c02bfe6573 |
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| cites | cdi_FETCH-LOGICAL-c390t-b03ce728db3ee66047eb9995ea91ee7e46f24ab41535796f14b2527c02bfe6573 |
| container_end_page | 83 |
| container_issue | 1 |
| container_start_page | 79 |
| container_title | Nuclear medicine and biology |
| container_volume | 26 |
| creator | Neves, M Gano, L Ribeiro, M.João Santos, A.Cristina Marchi, A Sawas-Dimopolou, C Pedroso de Lima, J.J |
| description | We report the synthesis, characterization, and biodistribution of
99mTc-complexes with the bidentate-
N,N chelate biguanide (Big) and the N1- substituted ligands dimethyl (DMBig), phenyl (PBig), and phenethyl (PEBig). Dynamic gamma-camera studies with
99mTc-Big and
99mTc-DMSA in rabbits indicated distinct renal and urinary excretion profiles.
99mTc-Big was cleared more quickly than
99mTc-DMSA, and for the same acquisition times, the contrast in whole-body images favored
99mTc-Big. Also, the estimated radiation absorbed doses by kidneys and blood for
99mTc-DMSA were significantly higher than for
99mTc-Big. These preliminary studies show that
99mTc-Big has favourable practical and dosimetric features for renal imaging as an alternative to
99mTc-DMSA. |
| doi_str_mv | 10.1016/S0969-8051(98)00074-2 |
| format | article |
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99mTc-complexes with the bidentate-
N,N chelate biguanide (Big) and the N1- substituted ligands dimethyl (DMBig), phenyl (PBig), and phenethyl (PEBig). Dynamic gamma-camera studies with
99mTc-Big and
99mTc-DMSA in rabbits indicated distinct renal and urinary excretion profiles.
99mTc-Big was cleared more quickly than
99mTc-DMSA, and for the same acquisition times, the contrast in whole-body images favored
99mTc-Big. Also, the estimated radiation absorbed doses by kidneys and blood for
99mTc-DMSA were significantly higher than for
99mTc-Big. These preliminary studies show that
99mTc-Big has favourable practical and dosimetric features for renal imaging as an alternative to
99mTc-DMSA.</description><identifier>ISSN: 0969-8051</identifier><identifier>EISSN: 1872-9614</identifier><identifier>DOI: 10.1016/S0969-8051(98)00074-2</identifier><identifier>PMID: 10096505</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>99mTc-Biguanides ; 99mTc-DMSA ; Animals ; Biguanides - chemical synthesis ; Biguanides - pharmacokinetics ; Biological and medical sciences ; Contrast media. Radiopharmaceuticals ; Female ; Kidney - diagnostic imaging ; Medical sciences ; Mice ; Organotechnetium Compounds - chemical synthesis ; Organotechnetium Compounds - pharmacokinetics ; Pharmacology. Drug treatments ; Protein Binding ; Rabbits ; Radionuclide Imaging ; Radiopharmaceuticals - pharmacokinetics ; Rats ; Rats, Wistar ; Renal imaging ; Technetium Tc 99m Dimercaptosuccinic Acid - pharmacokinetics ; Whole-Body Counting</subject><ispartof>Nuclear medicine and biology, 1999, Vol.26 (1), p.79-83</ispartof><rights>1999 Elsevier Science Inc.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-b03ce728db3ee66047eb9995ea91ee7e46f24ab41535796f14b2527c02bfe6573</citedby><cites>FETCH-LOGICAL-c390t-b03ce728db3ee66047eb9995ea91ee7e46f24ab41535796f14b2527c02bfe6573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4023,27922,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1682773$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10096505$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Neves, M</creatorcontrib><creatorcontrib>Gano, L</creatorcontrib><creatorcontrib>Ribeiro, M.João</creatorcontrib><creatorcontrib>Santos, A.Cristina</creatorcontrib><creatorcontrib>Marchi, A</creatorcontrib><creatorcontrib>Sawas-Dimopolou, C</creatorcontrib><creatorcontrib>Pedroso de Lima, J.J</creatorcontrib><title>Synthesis, characterization, and biodistribution of oxo complexes of technetium-99m with biguanide and N1-Substituted ligands</title><title>Nuclear medicine and biology</title><addtitle>Nucl Med Biol</addtitle><description>We report the synthesis, characterization, and biodistribution of
99mTc-complexes with the bidentate-
N,N chelate biguanide (Big) and the N1- substituted ligands dimethyl (DMBig), phenyl (PBig), and phenethyl (PEBig). Dynamic gamma-camera studies with
99mTc-Big and
99mTc-DMSA in rabbits indicated distinct renal and urinary excretion profiles.
99mTc-Big was cleared more quickly than
99mTc-DMSA, and for the same acquisition times, the contrast in whole-body images favored
99mTc-Big. Also, the estimated radiation absorbed doses by kidneys and blood for
99mTc-DMSA were significantly higher than for
99mTc-Big. These preliminary studies show that
99mTc-Big has favourable practical and dosimetric features for renal imaging as an alternative to
99mTc-DMSA.</description><subject>99mTc-Biguanides</subject><subject>99mTc-DMSA</subject><subject>Animals</subject><subject>Biguanides - chemical synthesis</subject><subject>Biguanides - pharmacokinetics</subject><subject>Biological and medical sciences</subject><subject>Contrast media. Radiopharmaceuticals</subject><subject>Female</subject><subject>Kidney - diagnostic imaging</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Organotechnetium Compounds - chemical synthesis</subject><subject>Organotechnetium Compounds - pharmacokinetics</subject><subject>Pharmacology. Drug treatments</subject><subject>Protein Binding</subject><subject>Rabbits</subject><subject>Radionuclide Imaging</subject><subject>Radiopharmaceuticals - pharmacokinetics</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Renal imaging</subject><subject>Technetium Tc 99m Dimercaptosuccinic Acid - pharmacokinetics</subject><subject>Whole-Body Counting</subject><issn>0969-8051</issn><issn>1872-9614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNqFkE1rFTEUhoMo9rb6E5RZiFToaJKZJJNVkeIXFF1cXYckc6b3yMzkmmS0Ffzv5n6g7lwdeM_znoSHkCeMvmSUyVdrqqWuOyrYue5eUEpVW_N7ZMU6xWstWXufrP4gJ-Q0pa-09FpGH5ITRstKULEiv9Z3c95AwnRR-Y2N1meI-NNmDPNFZee-chh6TDmiW3ZhFYYq3IbKh2k7wi2kXZDBb2bIuEy11lP1A_Om9G4WO2MP-ysfWb1eXMqYlwx9NeJNSdMj8mCwY4LHx3lGvrx98_nqfX396d2Hq9fXtW80zbWjjQfFu941AFLSVoHTWguwmgEoaOXAW-taJhqhtBxY67jgylPuBpBCNWfk-eHuNoZvC6RsJkwextHOEJZkZLHRSCkLKA6gjyGlCIPZRpxsvDOMmp13s_dudlKN7szeu-Gl9_T4wOIm6P9pHUQX4NkRsMnbcYh29pj-crLjSjUFuzxgUGx8R4gmeYTZQ48RfDZ9wP_85DfSAKDu</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>Neves, M</creator><creator>Gano, L</creator><creator>Ribeiro, M.João</creator><creator>Santos, A.Cristina</creator><creator>Marchi, A</creator><creator>Sawas-Dimopolou, C</creator><creator>Pedroso de Lima, J.J</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1999</creationdate><title>Synthesis, characterization, and biodistribution of oxo complexes of technetium-99m with biguanide and N1-Substituted ligands</title><author>Neves, M ; Gano, L ; Ribeiro, M.João ; Santos, A.Cristina ; Marchi, A ; Sawas-Dimopolou, C ; Pedroso de Lima, J.J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-b03ce728db3ee66047eb9995ea91ee7e46f24ab41535796f14b2527c02bfe6573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>99mTc-Biguanides</topic><topic>99mTc-DMSA</topic><topic>Animals</topic><topic>Biguanides - chemical synthesis</topic><topic>Biguanides - pharmacokinetics</topic><topic>Biological and medical sciences</topic><topic>Contrast media. Radiopharmaceuticals</topic><topic>Female</topic><topic>Kidney - diagnostic imaging</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Organotechnetium Compounds - chemical synthesis</topic><topic>Organotechnetium Compounds - pharmacokinetics</topic><topic>Pharmacology. Drug treatments</topic><topic>Protein Binding</topic><topic>Rabbits</topic><topic>Radionuclide Imaging</topic><topic>Radiopharmaceuticals - pharmacokinetics</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Renal imaging</topic><topic>Technetium Tc 99m Dimercaptosuccinic Acid - pharmacokinetics</topic><topic>Whole-Body Counting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Neves, M</creatorcontrib><creatorcontrib>Gano, L</creatorcontrib><creatorcontrib>Ribeiro, M.João</creatorcontrib><creatorcontrib>Santos, A.Cristina</creatorcontrib><creatorcontrib>Marchi, A</creatorcontrib><creatorcontrib>Sawas-Dimopolou, C</creatorcontrib><creatorcontrib>Pedroso de Lima, J.J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nuclear medicine and biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Neves, M</au><au>Gano, L</au><au>Ribeiro, M.João</au><au>Santos, A.Cristina</au><au>Marchi, A</au><au>Sawas-Dimopolou, C</au><au>Pedroso de Lima, J.J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis, characterization, and biodistribution of oxo complexes of technetium-99m with biguanide and N1-Substituted ligands</atitle><jtitle>Nuclear medicine and biology</jtitle><addtitle>Nucl Med Biol</addtitle><date>1999</date><risdate>1999</risdate><volume>26</volume><issue>1</issue><spage>79</spage><epage>83</epage><pages>79-83</pages><issn>0969-8051</issn><eissn>1872-9614</eissn><abstract>We report the synthesis, characterization, and biodistribution of
99mTc-complexes with the bidentate-
N,N chelate biguanide (Big) and the N1- substituted ligands dimethyl (DMBig), phenyl (PBig), and phenethyl (PEBig). Dynamic gamma-camera studies with
99mTc-Big and
99mTc-DMSA in rabbits indicated distinct renal and urinary excretion profiles.
99mTc-Big was cleared more quickly than
99mTc-DMSA, and for the same acquisition times, the contrast in whole-body images favored
99mTc-Big. Also, the estimated radiation absorbed doses by kidneys and blood for
99mTc-DMSA were significantly higher than for
99mTc-Big. These preliminary studies show that
99mTc-Big has favourable practical and dosimetric features for renal imaging as an alternative to
99mTc-DMSA.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>10096505</pmid><doi>10.1016/S0969-8051(98)00074-2</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0969-8051 |
| ispartof | Nuclear medicine and biology, 1999, Vol.26 (1), p.79-83 |
| issn | 0969-8051 1872-9614 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69653666 |
| source | ScienceDirect Journals |
| subjects | 99mTc-Biguanides 99mTc-DMSA Animals Biguanides - chemical synthesis Biguanides - pharmacokinetics Biological and medical sciences Contrast media. Radiopharmaceuticals Female Kidney - diagnostic imaging Medical sciences Mice Organotechnetium Compounds - chemical synthesis Organotechnetium Compounds - pharmacokinetics Pharmacology. Drug treatments Protein Binding Rabbits Radionuclide Imaging Radiopharmaceuticals - pharmacokinetics Rats Rats, Wistar Renal imaging Technetium Tc 99m Dimercaptosuccinic Acid - pharmacokinetics Whole-Body Counting |
| title | Synthesis, characterization, and biodistribution of oxo complexes of technetium-99m with biguanide and N1-Substituted ligands |
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