Ultrastructural Interactions in the Microvasculature of Human Endometrial Adenocarcinoma

Objectives.Our purpose was to study the ultrastructural morphology of the microvasculature of human endometrial adenocarcinoma and to determine the effect of this malignancy on cell-to-cell communication between the components of the microvasculature and with the other tissue compartments of human e...

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Bibliographic Details
Published in:Gynecologic oncology 1999-04, Vol.73 (1), p.76-86
Main Authors: Horbelt, Douglas V., Roberts, Daniel K., Parmley, Tim H., Delmore, James E., Walker-Bupp, Nola J.
Format: Article
Language:English
Subjects:
adenocarcinoma
Adenocarcinoma - blood supply
Adenocarcinoma - ultrastructure
angiogenesis
Biological and medical sciences
Cell Communication
Endometrial Neoplasms - blood supply
Endometrial Neoplasms - ultrastructure
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
human endometrium
Humans
Medical sciences
Microcirculation
microvasculature
Tumors
ultrastructure
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Summary:Objectives.Our purpose was to study the ultrastructural morphology of the microvasculature of human endometrial adenocarcinoma and to determine the effect of this malignancy on cell-to-cell communication between the components of the microvasculature and with the other tissue compartments of human endometrium. Methods.Multiple cases of human endometrial adenocarcinoma were studied and graded by light microscopy. Six cases of Grade I and six cases of Grade II were selected. Two blocks per case were studied ultrastructurally. Results.In contrast to our expectation that the ultrastructure of tumor vessels would suggest a great deal of proliferation and new vessel formation, we found that tumor vessels displayed a high degree of cellular differentiation, in the form of numerous and varied cell-to-cell contacts, and large amounts of protein production. Conclusions.The morphology of the microvasculature of endometrial adenocarcinoma suggests an active rather than passive role in tumor vessels.
ISSN:0090-8258
1095-6859
DOI:10.1006/gyno.1998.5333