Regional and cellular localization of calcitonin gene-related peptide-receptor component protein mRNA in the guinea-pig central nervous system

Recent cloning studies have isolated proteins which confer responsiveness to calcitonin gene-related peptide (CGRP). In this study, we have determined the central nervous system (CNS) distribution of the mRNA of one such protein, termed CGRP-receptor component protein (RCP), by in situ hybridization...

Full description

Saved in:
Bibliographic Details
Published in:Brain research. Molecular brain research. 1999-03, Vol.66 (1), p.205-210
Main Authors: Oliver, Kevin R, Wainwright, Anna, Kinsey, Anna M, Heavens, Robert P, Sirinathsinghji, Dalip J.S, Hill, Raymond G
Format: Article
Language:English
Subjects:
Anatomy
Animals
Biological and medical sciences
Brain Chemistry - genetics
Central nervous system
Central Nervous System - chemistry
Central Nervous System - physiology
CGRP receptor
CGRP-RCP
Fundamental and applied biological sciences. Psychology
Gene Expression - physiology
Guinea Pigs
Guinea-pig brain
In Situ Hybridization
Iodine Radioisotopes
Male
Oligonucleotide
Oligonucleotide Probes
Receptors, Calcitonin Gene-Related Peptide - genetics
RNA, Messenger - analysis
Vertebrates: nervous system and sense organs
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Recent cloning studies have isolated proteins which confer responsiveness to calcitonin gene-related peptide (CGRP). In this study, we have determined the central nervous system (CNS) distribution of the mRNA of one such protein, termed CGRP-receptor component protein (RCP), by in situ hybridization. CGRP–RCP mRNA was widely expressed in the guinea-pig CNS, being particularly abundant in cerebellum and hippocampus. These data should assist in the determination of the potential physiological function(s) of this protein in the CNS.
ISSN:0169-328X
1872-6941
DOI:10.1016/S0169-328X(99)00036-4