New BZLF1 sequence variations in EBV-associated undifferentiated nasopharyngeal carcinoma in southern China

The viral lytic gene BZLF1 triggers replication of the Epstein-Barr virus (EBV), which is commonly found in nasopharyngeal carcinoma (NPC). Here, RT-PCR revealed five new BZLF1 variants in 8 of 12 NPC and 4 of 12 non-NPC nasopharyngeal biopsies from an NPC-endemic area in southern China. The deduced...

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Bibliographic Details
Published in:Archives of virology 2008-10, Vol.153 (10), p.1949-1953
Main Authors: Ji, Kun-Mei, Li, Chun-Lin, Meng, Guang, Han, Ai-Dong, Wu, Xu-Li
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Amino Acid Substitution - genetics
Antibodies, Viral - blood
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Biopsy
Brief Report
Cancer
Carcinoma - virology
China
Cloning
DNA, Viral - chemistry
DNA, Viral - genetics
Epstein-Barr virus
Female
Fundamental and applied biological sciences. Psychology
Herpesvirus 4, Human - classification
Herpesvirus 4, Human - genetics
Herpesvirus 4, Human - isolation & purification
Humans
Infectious Diseases
Male
Medical Microbiology
Medical research
Medical sciences
Microbiology
Miscellaneous
Molecular Sequence Data
Nasopharyngeal Neoplasms - virology
Otolaryngology
Pathogenesis
Sequence Analysis, DNA
Trans-Activators - genetics
Tumors
Virology
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Description
Summary:The viral lytic gene BZLF1 triggers replication of the Epstein-Barr virus (EBV), which is commonly found in nasopharyngeal carcinoma (NPC). Here, RT-PCR revealed five new BZLF1 variants in 8 of 12 NPC and 4 of 12 non-NPC nasopharyngeal biopsies from an NPC-endemic area in southern China. The deduced peptide sequence of the dominant BZLF1 variant differed by 11 amino acids from that of the prototypical strain B95.8 (V01555). Anti-ZEBRA antibody levels were higher in NPC than that in non-NPC patients (P < 0.001). These findings demonstrated a dominant BZLF1 variant in southern Chinese EBV-associated NPC and non-NPC patients.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-008-0195-6