New BZLF1 sequence variations in EBV-associated undifferentiated nasopharyngeal carcinoma in southern China

The viral lytic gene BZLF1 triggers replication of the Epstein-Barr virus (EBV), which is commonly found in nasopharyngeal carcinoma (NPC). Here, RT-PCR revealed five new BZLF1 variants in 8 of 12 NPC and 4 of 12 non-NPC nasopharyngeal biopsies from an NPC-endemic area in southern China. The deduced...

Full description

Saved in:
Bibliographic Details
Published in:Archives of virology 2008-10, Vol.153 (10), p.1949-1953
Main Authors: Ji, Kun-Mei, Li, Chun-Lin, Meng, Guang, Han, Ai-Dong, Wu, Xu-Li
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Amino Acid Substitution - genetics
Antibodies, Viral - blood
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Biopsy
Brief Report
Cancer
Carcinoma - virology
China
Cloning
DNA, Viral - chemistry
DNA, Viral - genetics
Epstein-Barr virus
Female
Fundamental and applied biological sciences. Psychology
Herpesvirus 4, Human - classification
Herpesvirus 4, Human - genetics
Herpesvirus 4, Human - isolation & purification
Humans
Infectious Diseases
Male
Medical Microbiology
Medical research
Medical sciences
Microbiology
Miscellaneous
Molecular Sequence Data
Nasopharyngeal Neoplasms - virology
Otolaryngology
Pathogenesis
Sequence Analysis, DNA
Trans-Activators - genetics
Tumors
Virology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c454t-426844d9c4d222eb660eb3efa518d8646f20d5806751415140a9b425dc2206103
cites cdi_FETCH-LOGICAL-c454t-426844d9c4d222eb660eb3efa518d8646f20d5806751415140a9b425dc2206103
container_end_page 1953
container_issue 10
container_start_page 1949
container_title Archives of virology
container_volume 153
creator Ji, Kun-Mei
Li, Chun-Lin
Meng, Guang
Han, Ai-Dong
Wu, Xu-Li
description The viral lytic gene BZLF1 triggers replication of the Epstein-Barr virus (EBV), which is commonly found in nasopharyngeal carcinoma (NPC). Here, RT-PCR revealed five new BZLF1 variants in 8 of 12 NPC and 4 of 12 non-NPC nasopharyngeal biopsies from an NPC-endemic area in southern China. The deduced peptide sequence of the dominant BZLF1 variant differed by 11 amino acids from that of the prototypical strain B95.8 (V01555). Anti-ZEBRA antibody levels were higher in NPC than that in non-NPC patients (P < 0.001). These findings demonstrated a dominant BZLF1 variant in southern Chinese EBV-associated NPC and non-NPC patients.
doi_str_mv 10.1007/s00705-008-0195-6
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69656312</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69656312</sourcerecordid><originalsourceid>FETCH-LOGICAL-c454t-426844d9c4d222eb660eb3efa518d8646f20d5806751415140a9b425dc2206103</originalsourceid><addsrcrecordid>eNqFkU9v1DAQxS0EotvCB-ACERLcAjP-F-dIVy1FWpUDlAMXy-s4XZesvbWTIr59vcqKShzKwbY0_r3nGT9CXiF8QIDmYy4biBpA1YCtqOUTskDOaK2aVj0lC2DAayVBHZHjnG8ASoGJ5-QIlYIGUSzIr0v3uzr9uTrHKrvbyQXrqjuTvBl9DLnyoTo7_VGbnKMtNddVU-h837vkwjgXgslxtzHpT7h2ZqisSdaHuDV7bY7TuHEpVMuND-YFedabIbuXh_OEXJ2ffV9e1Kuvn78sP61qywUfa06l4rxrLe8opW4tJbg1c70RqDoluewpdEKBbARyLAtMu-ZUdJZSkAjshLyffXcplpHyqLc-WzcMJrg4ZS1bKSRD-l-QIgilUBTw7T_gTZxSKEMUhnJUvFEFwhmyKeacXK93yW_Lx2gEvc9Lz3npkpfe56Vl0bw-GE_rreseFIeACvDuAJhszdAnE6zPf7nSYcsa2M9MZy6Xq5JEeujwsdffzKLeRG2uUzG--kYBGaAQyCSye9fNtIE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>212418478</pqid></control><display><type>article</type><title>New BZLF1 sequence variations in EBV-associated undifferentiated nasopharyngeal carcinoma in southern China</title><source>Springer Nature</source><creator>Ji, Kun-Mei ; Li, Chun-Lin ; Meng, Guang ; Han, Ai-Dong ; Wu, Xu-Li</creator><creatorcontrib>Ji, Kun-Mei ; Li, Chun-Lin ; Meng, Guang ; Han, Ai-Dong ; Wu, Xu-Li</creatorcontrib><description>The viral lytic gene BZLF1 triggers replication of the Epstein-Barr virus (EBV), which is commonly found in nasopharyngeal carcinoma (NPC). Here, RT-PCR revealed five new BZLF1 variants in 8 of 12 NPC and 4 of 12 non-NPC nasopharyngeal biopsies from an NPC-endemic area in southern China. The deduced peptide sequence of the dominant BZLF1 variant differed by 11 amino acids from that of the prototypical strain B95.8 (V01555). Anti-ZEBRA antibody levels were higher in NPC than that in non-NPC patients (P &lt; 0.001). These findings demonstrated a dominant BZLF1 variant in southern Chinese EBV-associated NPC and non-NPC patients.</description><identifier>ISSN: 0304-8608</identifier><identifier>EISSN: 1432-8798</identifier><identifier>DOI: 10.1007/s00705-008-0195-6</identifier><identifier>PMID: 18807115</identifier><language>eng</language><publisher>Vienna: Vienna : Springer Vienna</publisher><subject>Amino Acid Sequence ; Amino Acid Substitution - genetics ; Antibodies, Viral - blood ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Biopsy ; Brief Report ; Cancer ; Carcinoma - virology ; China ; Cloning ; DNA, Viral - chemistry ; DNA, Viral - genetics ; Epstein-Barr virus ; Female ; Fundamental and applied biological sciences. Psychology ; Herpesvirus 4, Human - classification ; Herpesvirus 4, Human - genetics ; Herpesvirus 4, Human - isolation &amp; purification ; Humans ; Infectious Diseases ; Male ; Medical Microbiology ; Medical research ; Medical sciences ; Microbiology ; Miscellaneous ; Molecular Sequence Data ; Nasopharyngeal Neoplasms - virology ; Otolaryngology ; Pathogenesis ; Sequence Analysis, DNA ; Trans-Activators - genetics ; Tumors ; Virology</subject><ispartof>Archives of virology, 2008-10, Vol.153 (10), p.1949-1953</ispartof><rights>Springer-Verlag 2008</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-426844d9c4d222eb660eb3efa518d8646f20d5806751415140a9b425dc2206103</citedby><cites>FETCH-LOGICAL-c454t-426844d9c4d222eb660eb3efa518d8646f20d5806751415140a9b425dc2206103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=21093700$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18807115$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ji, Kun-Mei</creatorcontrib><creatorcontrib>Li, Chun-Lin</creatorcontrib><creatorcontrib>Meng, Guang</creatorcontrib><creatorcontrib>Han, Ai-Dong</creatorcontrib><creatorcontrib>Wu, Xu-Li</creatorcontrib><title>New BZLF1 sequence variations in EBV-associated undifferentiated nasopharyngeal carcinoma in southern China</title><title>Archives of virology</title><addtitle>Arch Virol</addtitle><addtitle>Arch Virol</addtitle><description>The viral lytic gene BZLF1 triggers replication of the Epstein-Barr virus (EBV), which is commonly found in nasopharyngeal carcinoma (NPC). Here, RT-PCR revealed five new BZLF1 variants in 8 of 12 NPC and 4 of 12 non-NPC nasopharyngeal biopsies from an NPC-endemic area in southern China. The deduced peptide sequence of the dominant BZLF1 variant differed by 11 amino acids from that of the prototypical strain B95.8 (V01555). Anti-ZEBRA antibody levels were higher in NPC than that in non-NPC patients (P &lt; 0.001). These findings demonstrated a dominant BZLF1 variant in southern Chinese EBV-associated NPC and non-NPC patients.</description><subject>Amino Acid Sequence</subject><subject>Amino Acid Substitution - genetics</subject><subject>Antibodies, Viral - blood</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biopsy</subject><subject>Brief Report</subject><subject>Cancer</subject><subject>Carcinoma - virology</subject><subject>China</subject><subject>Cloning</subject><subject>DNA, Viral - chemistry</subject><subject>DNA, Viral - genetics</subject><subject>Epstein-Barr virus</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Herpesvirus 4, Human - classification</subject><subject>Herpesvirus 4, Human - genetics</subject><subject>Herpesvirus 4, Human - isolation &amp; purification</subject><subject>Humans</subject><subject>Infectious Diseases</subject><subject>Male</subject><subject>Medical Microbiology</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Molecular Sequence Data</subject><subject>Nasopharyngeal Neoplasms - virology</subject><subject>Otolaryngology</subject><subject>Pathogenesis</subject><subject>Sequence Analysis, DNA</subject><subject>Trans-Activators - genetics</subject><subject>Tumors</subject><subject>Virology</subject><issn>0304-8608</issn><issn>1432-8798</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqFkU9v1DAQxS0EotvCB-ACERLcAjP-F-dIVy1FWpUDlAMXy-s4XZesvbWTIr59vcqKShzKwbY0_r3nGT9CXiF8QIDmYy4biBpA1YCtqOUTskDOaK2aVj0lC2DAayVBHZHjnG8ASoGJ5-QIlYIGUSzIr0v3uzr9uTrHKrvbyQXrqjuTvBl9DLnyoTo7_VGbnKMtNddVU-h837vkwjgXgslxtzHpT7h2ZqisSdaHuDV7bY7TuHEpVMuND-YFedabIbuXh_OEXJ2ffV9e1Kuvn78sP61qywUfa06l4rxrLe8opW4tJbg1c70RqDoluewpdEKBbARyLAtMu-ZUdJZSkAjshLyffXcplpHyqLc-WzcMJrg4ZS1bKSRD-l-QIgilUBTw7T_gTZxSKEMUhnJUvFEFwhmyKeacXK93yW_Lx2gEvc9Lz3npkpfe56Vl0bw-GE_rreseFIeACvDuAJhszdAnE6zPf7nSYcsa2M9MZy6Xq5JEeujwsdffzKLeRG2uUzG--kYBGaAQyCSye9fNtIE</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Ji, Kun-Mei</creator><creator>Li, Chun-Lin</creator><creator>Meng, Guang</creator><creator>Han, Ai-Dong</creator><creator>Wu, Xu-Li</creator><general>Vienna : Springer Vienna</general><general>Springer Vienna</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20081001</creationdate><title>New BZLF1 sequence variations in EBV-associated undifferentiated nasopharyngeal carcinoma in southern China</title><author>Ji, Kun-Mei ; Li, Chun-Lin ; Meng, Guang ; Han, Ai-Dong ; Wu, Xu-Li</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-426844d9c4d222eb660eb3efa518d8646f20d5806751415140a9b425dc2206103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Amino Acid Sequence</topic><topic>Amino Acid Substitution - genetics</topic><topic>Antibodies, Viral - blood</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Biopsy</topic><topic>Brief Report</topic><topic>Cancer</topic><topic>Carcinoma - virology</topic><topic>China</topic><topic>Cloning</topic><topic>DNA, Viral - chemistry</topic><topic>DNA, Viral - genetics</topic><topic>Epstein-Barr virus</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Herpesvirus 4, Human - classification</topic><topic>Herpesvirus 4, Human - genetics</topic><topic>Herpesvirus 4, Human - isolation &amp; purification</topic><topic>Humans</topic><topic>Infectious Diseases</topic><topic>Male</topic><topic>Medical Microbiology</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Molecular Sequence Data</topic><topic>Nasopharyngeal Neoplasms - virology</topic><topic>Otolaryngology</topic><topic>Pathogenesis</topic><topic>Sequence Analysis, DNA</topic><topic>Trans-Activators - genetics</topic><topic>Tumors</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ji, Kun-Mei</creatorcontrib><creatorcontrib>Li, Chun-Lin</creatorcontrib><creatorcontrib>Meng, Guang</creatorcontrib><creatorcontrib>Han, Ai-Dong</creatorcontrib><creatorcontrib>Wu, Xu-Li</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ji, Kun-Mei</au><au>Li, Chun-Lin</au><au>Meng, Guang</au><au>Han, Ai-Dong</au><au>Wu, Xu-Li</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New BZLF1 sequence variations in EBV-associated undifferentiated nasopharyngeal carcinoma in southern China</atitle><jtitle>Archives of virology</jtitle><stitle>Arch Virol</stitle><addtitle>Arch Virol</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>153</volume><issue>10</issue><spage>1949</spage><epage>1953</epage><pages>1949-1953</pages><issn>0304-8608</issn><eissn>1432-8798</eissn><abstract>The viral lytic gene BZLF1 triggers replication of the Epstein-Barr virus (EBV), which is commonly found in nasopharyngeal carcinoma (NPC). Here, RT-PCR revealed five new BZLF1 variants in 8 of 12 NPC and 4 of 12 non-NPC nasopharyngeal biopsies from an NPC-endemic area in southern China. The deduced peptide sequence of the dominant BZLF1 variant differed by 11 amino acids from that of the prototypical strain B95.8 (V01555). Anti-ZEBRA antibody levels were higher in NPC than that in non-NPC patients (P &lt; 0.001). These findings demonstrated a dominant BZLF1 variant in southern Chinese EBV-associated NPC and non-NPC patients.</abstract><cop>Vienna</cop><pub>Vienna : Springer Vienna</pub><pmid>18807115</pmid><doi>10.1007/s00705-008-0195-6</doi><tpages>5</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0304-8608
ispartof Archives of virology, 2008-10, Vol.153 (10), p.1949-1953
issn 0304-8608
1432-8798
language eng
recordid cdi_proquest_miscellaneous_69656312
source Springer Nature
subjects Amino Acid Sequence
Amino Acid Substitution - genetics
Antibodies, Viral - blood
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Biopsy
Brief Report
Cancer
Carcinoma - virology
China
Cloning
DNA, Viral - chemistry
DNA, Viral - genetics
Epstein-Barr virus
Female
Fundamental and applied biological sciences. Psychology
Herpesvirus 4, Human - classification
Herpesvirus 4, Human - genetics
Herpesvirus 4, Human - isolation & purification
Humans
Infectious Diseases
Male
Medical Microbiology
Medical research
Medical sciences
Microbiology
Miscellaneous
Molecular Sequence Data
Nasopharyngeal Neoplasms - virology
Otolaryngology
Pathogenesis
Sequence Analysis, DNA
Trans-Activators - genetics
Tumors
Virology
title New BZLF1 sequence variations in EBV-associated undifferentiated nasopharyngeal carcinoma in southern China
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T16%3A40%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=New%20BZLF1%20sequence%20variations%20in%20EBV-associated%20undifferentiated%20nasopharyngeal%20carcinoma%20in%20southern%20China&rft.jtitle=Archives%20of%20virology&rft.au=Ji,%20Kun-Mei&rft.date=2008-10-01&rft.volume=153&rft.issue=10&rft.spage=1949&rft.epage=1953&rft.pages=1949-1953&rft.issn=0304-8608&rft.eissn=1432-8798&rft_id=info:doi/10.1007/s00705-008-0195-6&rft_dat=%3Cproquest_cross%3E69656312%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c454t-426844d9c4d222eb660eb3efa518d8646f20d5806751415140a9b425dc2206103%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=212418478&rft_id=info:pmid/18807115&rfr_iscdi=true