Epidermal growth factor receptor expression in primary laryngeal cancer: An independent prognostic factor of neck node relapse

Specimens of laryngeal squamous cell carcinoma (LSCC) were examined for epidermal growth factor receptor (EGFR) content using a radioreceptor method; 140 untreated consecutive patients with primary LSCC undergoing initial surgical resection were followed up for a median of 49 months (range 2–84 mont...

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Bibliographic Details
Published in:International journal of cancer 1999-04, Vol.84 (2), p.188-191
Main Authors: Almadori, Giovanni, Cadoni, Gabriella, Galli, Jacopo, Ferrandina, Gabriella, Scambia, Giovanni, Exarchakos, Giorgio, Paludetti, Gaetano, Ottaviani, Fabrizio
Format: Article
Language:English
Subjects:
Analysis of Variance
Biological and medical sciences
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - surgery
Disease-Free Survival
ErbB Receptors - metabolism
Humans
Laryngeal Neoplasms - metabolism
Laryngeal Neoplasms - pathology
Laryngeal Neoplasms - surgery
Lymphatic Metastasis
Medical sciences
Middle Aged
Neck
Otorhinolaryngology. Stomatology
Prognosis
Regression Analysis
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Specimens of laryngeal squamous cell carcinoma (LSCC) were examined for epidermal growth factor receptor (EGFR) content using a radioreceptor method; 140 untreated consecutive patients with primary LSCC undergoing initial surgical resection were followed up for a median of 49 months (range 2–84 months) after surgery. Cox univariate regression analysis using EGFR as a continuous variable showed that EGFR levels were directly associated with the risk of lymph node metastasis. A significant relationship between EGFR status and cervical node metastasis was observed. The cutoff value of 20 fmol/mg protein was the best prognostic discriminator. The 5‐year metastasis‐free survival (MFS) was 66% for patients with EGFR− tumors compared with 15% for patients with EGFR+ tumors. By multivariate analysis, the EGFR status appeared to be a significant independent prognostic factor for MFS. Our results suggest that the assessment of EGFR status at the time of diagnosis may identify a subset of LSCC patients highly susceptible to neck node metastases thus defining therapy accordingly. Int. J. Cancer (Pred. Oncol.) 84:188–191, 1999. © 1999 Wiley‐Liss, Inc.
ISSN:0020-7136
1097-0215
DOI:10.1002/(SICI)1097-0215(19990420)84:2<188::AID-IJC16>3.0.CO;2-1