Ethanol induced differences in medial prefrontal cortex dopamine asymmetry and in nucleus accumbens dopamine metabolism in left- and right-turning rats

Ethanol (0.5 g/kg i.p.) 15 min prior to sacrifice increased homovanillic acid (HVA) levels in the left medial prefrontal cortex (mPFC) of left-turning rats and in the right mPFC of right-turning rats. In the nucleus accumbens (NAS), ethanol decreased dopamine (DA), 3,4-dihydroxyphenylacetic acid (DO...

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Bibliographic Details
Published in:Brain research 1999-03, Vol.823 (1), p.207-212
Main Authors: Nielsen, Darci M., Crosley, Kathleen J., Keller, Richard W., Glick, Stanley D., Carlson, Jeffrey N.
Format: Article
Language:English
Subjects:
3,4-Dihydroxyphenylacetic Acid - metabolism
Animals
Behavioral psychophysiology
Biological and medical sciences
Brain asymmetry
Dopamine
Dopamine - metabolism
Ethanol
Ethanol - pharmacology
Functional Laterality - physiology
Fundamental and applied biological sciences. Psychology
Homovanillic Acid - metabolism
Locomotor activity behavior
Male
Medial prefrontal cortex
Neurotransmission and behavior
Nucleus accumbens
Nucleus Accumbens - metabolism
Prefrontal Cortex - metabolism
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Rats, Long-Evans
Stereotyped Behavior - physiology
Tissue Distribution
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Summary:Ethanol (0.5 g/kg i.p.) 15 min prior to sacrifice increased homovanillic acid (HVA) levels in the left medial prefrontal cortex (mPFC) of left-turning rats and in the right mPFC of right-turning rats. In the nucleus accumbens (NAS), ethanol decreased dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), and HVA levels in rats that exhibited low levels of locomotor activity but not in rats that exhibited high levels of locomotor activity. This laboratory has previously shown that rats exhibiting differences in turning and locomotor activity behavior display different preferences for ethanol. The present results suggest that ethanol-induced differences in mPFC and NAS DA activity may be related to individual differences in the susceptibility to abuse ethanol.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(99)01129-4