Prevalence and risk factors of hepatic steatosis and its impact on liver injury in Chinese patients with chronic hepatitis B infection

• Published in: Journal of gastroenterology and hepatology 2008-09, Vol.23 (9), p.1419-1425
• Main Authors: Shi, Jun-ping, Fan, Jian-gao, Wu, Rui, Gao, Xiao-qian, Zhang, Li, Wang, Hao, Farrell, Geoffrey C
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Asian Continental Ancestry Group - statistics & numerical data; Biological and medical sciences; Child; China - epidemiology; chronic hepatitis B; Fatty Liver - ethnology; Fatty Liver - etiology; Fatty Liver - metabolism; Fatty Liver - pathology; Fatty Liver - virology; Female; Gastroenterology. Liver. Pancreas. Abdomen; Hepatitis B virus; Hepatitis B, Chronic - complications; Hepatitis B, Chronic - ethnology; Hepatitis B, Chronic - metabolism; Hepatitis B, Chronic - pathology; Human viral diseases; Humans; Infectious diseases; Liver - pathology; Liver - virology; Liver Cirrhosis - ethnology; Liver Cirrhosis - pathology; Liver Cirrhosis - virology; liver fibrosis; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Metabolic diseases; metabolic syndrome; Middle Aged; Miscellaneous; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; Other diseases. Semiology; Other metabolic disorders; Prevalence; Risk Factors; Severity of Illness Index; Sex Factors; Viral diseases; Viral hepatitis; Young Adult
• ISSN: 0815-9319; 1440-1746
• DOI: 10.1111/j.1440-1746.2008.05531.x

Background and Aims:  The clinical significance of hepatic steatosis in chronic hepatitis B infection (CHB) is unclear. The aims of this study were thus to investigate the prevalence and risk factors for hepatic steatosis in patients with CHB and its relationship with liver injury. Methods:  Consecutive patients with biopsy‐proven CHB at Hangzhou Sixth People's Hospital between January 2005 and June 2007 were included. Patients co‐infected with other viruses or suffering from liver disease of any other cause were excluded. Liver steatosis, necroinflammation and fibrosis were assessed by both Brunt and Scheuer classifications. Results:  A total of 1915 patients (1497 men) with a mean age of 31 ± 9.5 years were analyzed. Hepatic steatosis was present in 260 (14%) patients. The steatosis involved