Eradication of Helicobacter pylori increases gastric acidity in patients with atrophic gastritis of the corpus—evaluation of 24‐h pH monitoring

Background: Recent studies have shown that the eradication of Helicobacter pylori results in a gastric acid secretion which decreases to normal levels in patients with duodenal ulcer disease. The aim of this study was to evaluate the effect of eradication of H. pylori in a 24‐h study of gastric acid...

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Bibliographic Details
Published in:Alimentary pharmacology & therapeutics 1999-02, Vol.13 (2), p.155-162
Main Authors: HARUMA, K, MIHARA, M, OKAMOTO, E, KUSUNOKI, H, HANANOKI, M, TANAKA, S, YOSHIHARA, M, SUMII, K, KAJIYAMA, G
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Digestive system
Female
Gastric Acid - metabolism
Gastric Acidity Determination
Gastritis, Atrophic - metabolism
Helicobacter pylori - drug effects
Humans
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Stomach Neoplasms - etiology
Time Factors
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Summary:Background: Recent studies have shown that the eradication of Helicobacter pylori results in a gastric acid secretion which decreases to normal levels in patients with duodenal ulcer disease. The aim of this study was to evaluate the effect of eradication of H. pylori in a 24‐h study of gastric acidity in patients with atrophic gastritis of the corpus. Methods: Intragastric acidity was measured by continuous 24‐h pH monitoring, and the histology of the gastric antrum and corpus were evaluated in 14 H. pylori‐positive patients with histologically proven atrophic gastritis of the corpus (10 men, 4 women; mean age, 57 years) before and 1 year after anti‐H. pylori therapy. Results: H. pylori was absent in 13 of 14 patients 1 year after treatment. Both gastritis and atrophy scores were significantly lower after eradication therapy (P 
ISSN:0269-2813
1365-2036
DOI:10.1046/j.1365-2036.1999.00459.x