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Eradication of Helicobacter pylori increases gastric acidity in patients with atrophic gastritis of the corpus—evaluation of 24‐h pH monitoring
Background: Recent studies have shown that the eradication of Helicobacter pylori results in a gastric acid secretion which decreases to normal levels in patients with duodenal ulcer disease. The aim of this study was to evaluate the effect of eradication of H. pylori in a 24‐h study of gastric acid...
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| Published in: | Alimentary pharmacology & therapeutics 1999-02, Vol.13 (2), p.155-162 |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c4439-a85aab9f3425cd3a5564f26bd1c8353ce82056832ec7dc121fcf5467bc061d4a3 |
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| cites | cdi_FETCH-LOGICAL-c4439-a85aab9f3425cd3a5564f26bd1c8353ce82056832ec7dc121fcf5467bc061d4a3 |
| container_end_page | 162 |
| container_issue | 2 |
| container_start_page | 155 |
| container_title | Alimentary pharmacology & therapeutics |
| container_volume | 13 |
| creator | HARUMA, K MIHARA, M OKAMOTO, E KUSUNOKI, H HANANOKI, M TANAKA, S YOSHIHARA, M SUMII, K KAJIYAMA, G |
| description | Background:
Recent studies have shown that the eradication of Helicobacter pylori results in a gastric acid secretion which decreases to normal levels in patients with duodenal ulcer disease. The aim of this study was to evaluate the effect of eradication of H. pylori in a 24‐h study of gastric acidity in patients with atrophic gastritis of the corpus.
Methods:
Intragastric acidity was measured by continuous 24‐h pH monitoring, and the histology of the gastric antrum and corpus were evaluated in 14 H. pylori‐positive patients with histologically proven atrophic gastritis of the corpus (10 men, 4 women; mean age, 57 years) before and 1 year after anti‐H. pylori therapy.
Results:
H. pylori was absent in 13 of 14 patients 1 year after treatment. Both gastritis and atrophy scores were significantly lower after eradication therapy (P |
| doi_str_mv | 10.1046/j.1365-2036.1999.00459.x |
| format | article |
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Recent studies have shown that the eradication of Helicobacter pylori results in a gastric acid secretion which decreases to normal levels in patients with duodenal ulcer disease. The aim of this study was to evaluate the effect of eradication of H. pylori in a 24‐h study of gastric acidity in patients with atrophic gastritis of the corpus.
Methods:
Intragastric acidity was measured by continuous 24‐h pH monitoring, and the histology of the gastric antrum and corpus were evaluated in 14 H. pylori‐positive patients with histologically proven atrophic gastritis of the corpus (10 men, 4 women; mean age, 57 years) before and 1 year after anti‐H. pylori therapy.
Results:
H. pylori was absent in 13 of 14 patients 1 year after treatment. Both gastritis and atrophy scores were significantly lower after eradication therapy (P < 0.01). The 24‐h median pH and the percentage of 24‐h pH readings above 4.0 units were significantly decreased after eradication therapy (from 5.12 ± 0.36 to 2.69 ± 0.21, and from 65.5 ± 6.6% to 28.2 ± 6.1%, P < 0.01, respectively.)
Conclusion:
Eradication of H. pylori increases 24‐h gastric acidity in patients with atrophic gastritis of the corpus. Improvement of the histology of the gastric antrum and corpus may lead to the normalization of gastric acidity.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1046/j.1365-2036.1999.00459.x</identifier><identifier>PMID: 10102944</identifier><language>eng</language><publisher>Oxford UK: Blackwell Science Ltd</publisher><subject>Aged ; Biological and medical sciences ; Digestive system ; Female ; Gastric Acid - metabolism ; Gastric Acidity Determination ; Gastritis, Atrophic - metabolism ; Helicobacter pylori - drug effects ; Humans ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Stomach Neoplasms - etiology ; Time Factors</subject><ispartof>Alimentary pharmacology & therapeutics, 1999-02, Vol.13 (2), p.155-162</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4439-a85aab9f3425cd3a5564f26bd1c8353ce82056832ec7dc121fcf5467bc061d4a3</citedby><cites>FETCH-LOGICAL-c4439-a85aab9f3425cd3a5564f26bd1c8353ce82056832ec7dc121fcf5467bc061d4a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1695227$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10102944$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HARUMA, K</creatorcontrib><creatorcontrib>MIHARA, M</creatorcontrib><creatorcontrib>OKAMOTO, E</creatorcontrib><creatorcontrib>KUSUNOKI, H</creatorcontrib><creatorcontrib>HANANOKI, M</creatorcontrib><creatorcontrib>TANAKA, S</creatorcontrib><creatorcontrib>YOSHIHARA, M</creatorcontrib><creatorcontrib>SUMII, K</creatorcontrib><creatorcontrib>KAJIYAMA, G</creatorcontrib><title>Eradication of Helicobacter pylori increases gastric acidity in patients with atrophic gastritis of the corpus—evaluation of 24‐h pH monitoring</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Background:
Recent studies have shown that the eradication of Helicobacter pylori results in a gastric acid secretion which decreases to normal levels in patients with duodenal ulcer disease. The aim of this study was to evaluate the effect of eradication of H. pylori in a 24‐h study of gastric acidity in patients with atrophic gastritis of the corpus.
Methods:
Intragastric acidity was measured by continuous 24‐h pH monitoring, and the histology of the gastric antrum and corpus were evaluated in 14 H. pylori‐positive patients with histologically proven atrophic gastritis of the corpus (10 men, 4 women; mean age, 57 years) before and 1 year after anti‐H. pylori therapy.
Results:
H. pylori was absent in 13 of 14 patients 1 year after treatment. Both gastritis and atrophy scores were significantly lower after eradication therapy (P < 0.01). The 24‐h median pH and the percentage of 24‐h pH readings above 4.0 units were significantly decreased after eradication therapy (from 5.12 ± 0.36 to 2.69 ± 0.21, and from 65.5 ± 6.6% to 28.2 ± 6.1%, P < 0.01, respectively.)
Conclusion:
Eradication of H. pylori increases 24‐h gastric acidity in patients with atrophic gastritis of the corpus. Improvement of the histology of the gastric antrum and corpus may lead to the normalization of gastric acidity.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Digestive system</subject><subject>Female</subject><subject>Gastric Acid - metabolism</subject><subject>Gastric Acidity Determination</subject><subject>Gastritis, Atrophic - metabolism</subject><subject>Helicobacter pylori - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Stomach Neoplasms - etiology</subject><subject>Time Factors</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNqNkc1u1DAUhS0EotPCKyAvELsE_08ssamqwiBVgkVZW86N0_EoEwfboZ1dHwGJPmGfhISMCktW90r3O_dI5yCEKSkpEer9rqRcyYIRrkqqtS4JEVKXd8_Q6unwHK0IU7pgFeUn6DSlHSFErQl7iU4ooYRpIVbo12W0jQebfehxaPHGdR5CbSG7iIdDF6LHvofobHIJ39iUowdswTc-H6YLHiap63PCtz5vsc0xDNuJWMjs0_w0bx2GEIcxPd4_uB-2G5_8mHi8_7nFwwbvQ-_zZNffvEIvWtsl9_o4z9C3j5fXF5vi6sunzxfnVwUIwXVhK2ltrVsumISGWymVaJmqGwoVlxxcxYhUFWcO1g1QRltopVDrGoiijbD8DL1b_g4xfB9dymbvE7ius70LYzJKKyW5YhNYLSDEkFJ0rRmi39t4MJSYuRCzM3PuZs7dzIWYP4WYu0n65ugx1nvX_CNcGpiAt0fAJrBdG20PPv3llJaMrSfsw4Ld-s4d_tvfnH-9nhb-G05Iqzg</recordid><startdate>199902</startdate><enddate>199902</enddate><creator>HARUMA, K</creator><creator>MIHARA, M</creator><creator>OKAMOTO, E</creator><creator>KUSUNOKI, H</creator><creator>HANANOKI, M</creator><creator>TANAKA, S</creator><creator>YOSHIHARA, M</creator><creator>SUMII, K</creator><creator>KAJIYAMA, G</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199902</creationdate><title>Eradication of Helicobacter pylori increases gastric acidity in patients with atrophic gastritis of the corpus—evaluation of 24‐h pH monitoring</title><author>HARUMA, K ; MIHARA, M ; OKAMOTO, E ; KUSUNOKI, H ; HANANOKI, M ; TANAKA, S ; YOSHIHARA, M ; SUMII, K ; KAJIYAMA, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4439-a85aab9f3425cd3a5564f26bd1c8353ce82056832ec7dc121fcf5467bc061d4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Digestive system</topic><topic>Female</topic><topic>Gastric Acid - metabolism</topic><topic>Gastric Acidity Determination</topic><topic>Gastritis, Atrophic - metabolism</topic><topic>Helicobacter pylori - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Stomach Neoplasms - etiology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HARUMA, K</creatorcontrib><creatorcontrib>MIHARA, M</creatorcontrib><creatorcontrib>OKAMOTO, E</creatorcontrib><creatorcontrib>KUSUNOKI, H</creatorcontrib><creatorcontrib>HANANOKI, M</creatorcontrib><creatorcontrib>TANAKA, S</creatorcontrib><creatorcontrib>YOSHIHARA, M</creatorcontrib><creatorcontrib>SUMII, K</creatorcontrib><creatorcontrib>KAJIYAMA, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HARUMA, K</au><au>MIHARA, M</au><au>OKAMOTO, E</au><au>KUSUNOKI, H</au><au>HANANOKI, M</au><au>TANAKA, S</au><au>YOSHIHARA, M</au><au>SUMII, K</au><au>KAJIYAMA, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Eradication of Helicobacter pylori increases gastric acidity in patients with atrophic gastritis of the corpus—evaluation of 24‐h pH monitoring</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>1999-02</date><risdate>1999</risdate><volume>13</volume><issue>2</issue><spage>155</spage><epage>162</epage><pages>155-162</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>Background:
Recent studies have shown that the eradication of Helicobacter pylori results in a gastric acid secretion which decreases to normal levels in patients with duodenal ulcer disease. The aim of this study was to evaluate the effect of eradication of H. pylori in a 24‐h study of gastric acidity in patients with atrophic gastritis of the corpus.
Methods:
Intragastric acidity was measured by continuous 24‐h pH monitoring, and the histology of the gastric antrum and corpus were evaluated in 14 H. pylori‐positive patients with histologically proven atrophic gastritis of the corpus (10 men, 4 women; mean age, 57 years) before and 1 year after anti‐H. pylori therapy.
Results:
H. pylori was absent in 13 of 14 patients 1 year after treatment. Both gastritis and atrophy scores were significantly lower after eradication therapy (P < 0.01). The 24‐h median pH and the percentage of 24‐h pH readings above 4.0 units were significantly decreased after eradication therapy (from 5.12 ± 0.36 to 2.69 ± 0.21, and from 65.5 ± 6.6% to 28.2 ± 6.1%, P < 0.01, respectively.)
Conclusion:
Eradication of H. pylori increases 24‐h gastric acidity in patients with atrophic gastritis of the corpus. Improvement of the histology of the gastric antrum and corpus may lead to the normalization of gastric acidity.</abstract><cop>Oxford UK</cop><pub>Blackwell Science Ltd</pub><pmid>10102944</pmid><doi>10.1046/j.1365-2036.1999.00459.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0269-2813 |
| ispartof | Alimentary pharmacology & therapeutics, 1999-02, Vol.13 (2), p.155-162 |
| issn | 0269-2813 1365-2036 |
| language | eng |
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| source | Wiley |
| subjects | Aged Biological and medical sciences Digestive system Female Gastric Acid - metabolism Gastric Acidity Determination Gastritis, Atrophic - metabolism Helicobacter pylori - drug effects Humans Male Medical sciences Middle Aged Pharmacology. Drug treatments Stomach Neoplasms - etiology Time Factors |
| title | Eradication of Helicobacter pylori increases gastric acidity in patients with atrophic gastritis of the corpus—evaluation of 24‐h pH monitoring |
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