Therapeutic Use of Infliximab in Tuberculosis to Control Severe Paradoxical Reaction of the Brain and Lymph Nodes

Paradoxical reactions are immune-mediated exacerbations of disease triggered by tuberculosis treatment. Paradoxical reactions involving the central nervous system may be life threatening. Infliximab (tumor necrosis factor antibody) profoundly inhibits cellular immune responses to Mycobacterium tuber...

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Bibliographic Details
Published in:Clinical infectious diseases 2008-11, Vol.47 (10), p.e83-e85
Main Authors: Blackmore, Timothy K., Manning, Laurens, Taylor, William J., Wallis, Robert S.
Format: Article
Language:English
Subjects:
Adult
Anti-Inflammatory Agents - therapeutic use
Antibodies, Monoclonal - therapeutic use
Brain - drug effects
Brain - immunology
Brain - pathology
Female
Head - diagnostic imaging
Humans
Immunologic Factors - therapeutic use
Infliximab
Lymph Nodes - drug effects
Lymph Nodes - immunology
Lymph Nodes - pathology
Mycobacterium tuberculosis
Mycobacterium tuberculosis - immunology
Radiography
Steroids - therapeutic use
Tuberculosis - drug therapy
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Summary:Paradoxical reactions are immune-mediated exacerbations of disease triggered by tuberculosis treatment. Paradoxical reactions involving the central nervous system may be life threatening. Infliximab (tumor necrosis factor antibody) profoundly inhibits cellular immune responses to Mycobacterium tuberculosis. We describe a case in which infliximab was used to control steroid-resistant tuberculosis paradoxical reaction involving the central nervous system.
ISSN:1058-4838
1537-6591
DOI:10.1086/592695