Structure and anti-dengue virus activity of sulfated polysaccharide from a marine alga

A sulfated polysaccharide, named fucoidan, from the marine alga Cladosiphon okamuranus is comprised of carbohydrate units containing glucuronic acid and sulfated fucose residues. Here we found this compound potently inhibits dengue virus type 2 (DEN2) infection. Viral infection was inhibited when DE...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2008-11, Vol.376 (1), p.91-95
Main Authors: Hidari, Kazuya I.P.J., Takahashi, Naonori, Arihara, Masataka, Nagaoka, Masato, Morita, Koichi, Suzuki, Takashi
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Antiviral Agents - chemistry
Antiviral Agents - metabolism
Antiviral Agents - pharmacology
Cell Line
Cladosiphon okamuranus
Cricetinae
Dengue virus
Dengue Virus - drug effects
Dengue Virus - genetics
Dengue Virus - metabolism
Dengue virus type 2
Fucoidan
Glucuronic acid
Molecular Sequence Data
Phaeophyceae - chemistry
Polysaccharides - chemistry
Polysaccharides - metabolism
Polysaccharides - pharmacology
Protein Conformation
Protein Structure, Tertiary
Serotype
Structure-Activity Relationship
Sulfation
Viral Envelope Proteins - chemistry
Viral Envelope Proteins - genetics
Viral Envelope Proteins - metabolism
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Summary:A sulfated polysaccharide, named fucoidan, from the marine alga Cladosiphon okamuranus is comprised of carbohydrate units containing glucuronic acid and sulfated fucose residues. Here we found this compound potently inhibits dengue virus type 2 (DEN2) infection. Viral infection was inhibited when DEN2, but not other serotypes, was pretreated with fucoidan. A carboxy-reduced fucoidan derivative in which glucuronic acid was converted to glucose did not inhibit viral infection. Elimination of the sulfated function group from fucoidan significantly attenuated the inhibitory activity on DEN2 infection with
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2008.08.100