Simultaneous occurrence of Hodgkin's disease, nodal Langerhans' cell histiocytosis and multiple myeloma IgA(κ)

A 35-year-old man suffered simultaneously from nodular sclerosis Hodgkin's disease (HD), Langerhans' cell histiocytosis and multiple myeloma (MM). There was no prior history of irradiation or chemotherapy, and clinically the lymphoma was confined to cervical lymph nodes. Immunohistochemica...

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Published in:Virchows Archiv : an international journal of pathology 1999-03, Vol.434 (3), p.259-262
Main Authors: IBARROLA DE ANDRES, C, TOSCANO, R, LAHUERTA, J. J, MARTINEZ-GONZALEZ, M. A
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Hematologic and hematopoietic diseases
Histiocytosis, Langerhans-Cell - complications
Histiocytosis, Langerhans-Cell - metabolism
Histiocytosis, Langerhans-Cell - pathology
Hodgkin Disease - complications
Hodgkin Disease - metabolism
Hodgkin Disease - pathology
Humans
Immunoglobulins - metabolism
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymph Nodes - pathology
Male
Medical sciences
Multiple Myeloma - complications
Multiple Myeloma - metabolism
Multiple Myeloma - pathology
Plasma Cells - metabolism
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container_issue 3
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container_title Virchows Archiv : an international journal of pathology
container_volume 434
creator IBARROLA DE ANDRES, C
TOSCANO, R
LAHUERTA, J. J
MARTINEZ-GONZALEZ, M. A
description A 35-year-old man suffered simultaneously from nodular sclerosis Hodgkin's disease (HD), Langerhans' cell histiocytosis and multiple myeloma (MM). There was no prior history of irradiation or chemotherapy, and clinically the lymphoma was confined to cervical lymph nodes. Immunohistochemically, neoplastic lymphoma cells reacted with CD15 and CD30 markers. The patient's bone marrow exhibited a diffuse infiltration by rather atypical plasma cells showing kappa immunoglobulin light-chain restriction. At 14 months after the diagnosis, after autologous bone marrow transplantation, the clinical evolution is favourable with complete remission of the diseases. This is the first time that the coexistence of these three haematological disorders has been discussed, and only the fourth documented case of simultaneous HD and MM. Speculations about the significance of this finding are discussed.
doi_str_mv 10.1007/s004280050338
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subjects Adult
Biological and medical sciences
Hematologic and hematopoietic diseases
Histiocytosis, Langerhans-Cell - complications
Histiocytosis, Langerhans-Cell - metabolism
Histiocytosis, Langerhans-Cell - pathology
Hodgkin Disease - complications
Hodgkin Disease - metabolism
Hodgkin Disease - pathology
Humans
Immunoglobulins - metabolism
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymph Nodes - pathology
Male
Medical sciences
Multiple Myeloma - complications
Multiple Myeloma - metabolism
Multiple Myeloma - pathology
Plasma Cells - metabolism
title Simultaneous occurrence of Hodgkin's disease, nodal Langerhans' cell histiocytosis and multiple myeloma IgA(κ)
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