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Mycophenolic acid plasma concentrations in kidney allograft recipients with or without cyclosporin: a cross-sectional study

BACKGROUND: Combining cyclosporin (CsA) and prednisone with mycophenolate mofetil (MMF) results in a significant reduction in the rate of biopsy-proven acute rejection after kidney transplantation. This is achieved with a standard daily MMF dosage of 2 or 3 g. Whether monitoring of the pharmacologic...

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Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 1999-03, Vol.14 (3), p.706-708
Main Authors: Smak Gregoor, P J, van Gelder, T, Hesse, C J, van der Mast, B J, van Besouw, N M, Weimar, W
Format: Article
Language:English
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Summary:BACKGROUND: Combining cyclosporin (CsA) and prednisone with mycophenolate mofetil (MMF) results in a significant reduction in the rate of biopsy-proven acute rejection after kidney transplantation. This is achieved with a standard daily MMF dosage of 2 or 3 g. Whether monitoring of the pharmacologically active metabolite mycophenolic acid (MPA) will lead to improved safety and efficacy is unclear. METHODS: We monitored MPA trough levels in 18 kidney transplant recipients treated with CsA, prednisone, and MMF (63 samples) and in 11 patients (31 samples) treated with prednisone and MMF only, in a cross-sectional study. All patients were at least 3 months after transplantation with stable graft function. All patients were treated with 2 g MMF for at least 3 months and 10 mg prednisone. RESULTS: The MPA trough levels in the CsA-treated patients were significantly lower (P
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/14.3.706