Antiviral activity of some South American medicinal plants

Folk medicinal plants are potential sources of useful therapeutic compounds including some with antiviral activities. Extracts prepared from 10 South American medicinal plants (Baccharis trinervis, Baccharis teindalensis, Eupatorium articulatum, Eupatorium glutinosum, Tagetes pusilla, Neurolaena lob...

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Bibliographic Details
Published in:Phytotherapy research 1999-03, Vol.13 (2), p.142-146
Main Authors: Abad, M. J., Bermejo, P., Palomino, S. Sanchez, Carrasco, L., Chiriboga, X.
Format: Article
Language:English
Subjects:
antiviral activity
Antiviral Agents - pharmacology
Biological and medical sciences
Drug Evaluation, Preclinical
General pharmacology
HeLa Cells - drug effects
Herpesvirus 1, Human - drug effects
HSV-1
Humans
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Plant Extracts - pharmacology
Plants, Medicinal
poliovirus
Poliovirus - drug effects
South America
South American medicinal plants
Vesicular stomatitis Indiana virus - drug effects
VSV
VSV, poliovirus
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Summary:Folk medicinal plants are potential sources of useful therapeutic compounds including some with antiviral activities. Extracts prepared from 10 South American medicinal plants (Baccharis trinervis, Baccharis teindalensis, Eupatorium articulatum, Eupatorium glutinosum, Tagetes pusilla, Neurolaena lobata, Conyza floribunda, Phytolacca bogotensis, Phytolacca rivinoides and Heisteria acuminata) were screened for in vitro antiviral activity against herpes simplex type I (HSV‐1), vesicular stomatitis virus (VSV) and poliovirus type 1. The most potent inhibition was observed with an aqueous extract of B. trinervis, which inhibited HSV‐1 replication by 100% at 50–200 µg/mL, without showing cytotoxic effects. Good activities were also found with the ethanol extract of H. cuminata and the aqueous extract of E. articulatum, which exhibited antiviral effects against both DNA and RNA viruses (HSV‐1 and VSV, respectively) at 125–250 µg/mL. The aqueous extracts of T. pusilla (100–250 µg/mL), B. teindalensis (50–125 µg/mL) and E. glutinosum (50–125 µg/mL) also inhibited the replication of VSV, but none of the extracts tested had any effect on poliovirus replication. Copyright © 1999 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/(SICI)1099-1573(199903)13:2<142::AID-PTR392>3.0.CO;2-7