Prognostic value of vertebral lesions detected by magnetic resonance imaging in patients with stage I multiple myeloma

We assessed the role of spinal magnetic resonance imaging (MRI) and bone densitometry as prognostic factors in patients with asymptomatic stage I multiple myeloma (MM) and negative skeletal survey. 55 consecutive patients underwent spinal MRI and 41 of them underwent bone densitometry by dual‐energy...

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Bibliographic Details
Published in:British journal of haematology 1999-03, Vol.104 (4), p.723-729
Main Authors: Mariette, Xavier, Zagdanski, Anne‐Marie, Guermazi, Ali, Bergot, Catherine, Arnould, Anne, Frija, Jacques, Brouet, Jean‐Claude, Fermand, Jean‐Paul
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Adult
Aged
Aged, 80 and over
Biological and medical sciences
bone densitometry
Bone Density
bone lesion
Bone Marrow Neoplasms - diagnosis
Disease Progression
Female
Hematology
Humans
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulinopathies
Immunopathology
Lumbar Vertebrae
magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medical sciences
Middle Aged
multiple myeloma
Multiple Myeloma - diagnosis
Prognosis
prognostic factor
Spinal Diseases - diagnosis
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Summary:We assessed the role of spinal magnetic resonance imaging (MRI) and bone densitometry as prognostic factors in patients with asymptomatic stage I multiple myeloma (MM) and negative skeletal survey. 55 consecutive patients underwent spinal MRI and 41 of them underwent bone densitometry by dual‐energy X‐ray absorptiometry (DEXA). Spinal MRI studies showed evidence of bone marrow involvement in 17/55 patients (31%). A diffuse pattern was present in three patients and a focal pattern in 14 patients, nine of them with only one nodular lesion. During a median follow‐up of 25 months, 10 patients had disease progression, 8/17 patients with abnormal MRI and 2/38 patients with normal MRI. Median time to disease progression was not reached in both groups but was significantly different for patients with normal and those with abnormal patterns on MRI (P 
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.1999.01244.x