Microvascular protective activity of flavonoid glucuronides fraction from Tulipa gesneriana

A mixture of flavonoid glucuronides, consisting of 7‐O‐glucuronides of kaempferol and quercetin 3‐O‐rutinosides, 3‐O‐gentiobiosides and 3‐O‐glucosides, was isolated from the perianths of Tulipa gesneriana L. var. ‘Paradae’. It showed protective activity against the increased (both chloroform and his...

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Bibliographic Details
Published in:Phytotherapy research 1999-03, Vol.13 (2), p.166-168
Main Authors: Budzianowsk, Jaromir, Korzeniowska, Krystyna, Chmara, Ewa, Mrozikiewicz, Aleksander
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Capillary Permeability - drug effects
flavonoid glucuronides
Flavonoids - isolation & purification
Flavonoids - pharmacology
General pharmacology
Glucuronates - isolation & purification
Glucuronates - pharmacology
Liliaceae
Liliaceae - chemistry
Male
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - chemistry
Plant Extracts - pharmacology
Rabbits
Tulipa gesneriana
Vasoconstrictor Agents - isolation & purification
Vasoconstrictor Agents - pharmacology
vasoprotective activity
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Summary:A mixture of flavonoid glucuronides, consisting of 7‐O‐glucuronides of kaempferol and quercetin 3‐O‐rutinosides, 3‐O‐gentiobiosides and 3‐O‐glucosides, was isolated from the perianths of Tulipa gesneriana L. var. ‘Paradae’. It showed protective activity against the increased (both chloroform and histamine) skin vascular permeability in rabbits. The protective effect, measured as the reduction in leakage of Evans blue, was 59.8% after peritoneal treatment at a dose of 25 mg/kg, while that of troxerutin was 45.5%. Copyright © 1999 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/(SICI)1099-1573(199903)13:2<166::AID-PTR407>3.0.CO;2-L