The cerebellum in mild cognitive impairment and Alzheimer’s disease – A structural MRI study

Abstract Neuropathological research consistently revealed the cerebellum to undergo degenerative changes in Alzheimer’s disease (AD). Whether these alterations affect cerebellar morphology in vivo has not yet been investigated in a comprehensive way. Magnetic resonance imaging was performed in 20 pa...

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Bibliographic Details
Published in:Journal of psychiatric research 2008-10, Vol.42 (14), p.1198-1202
Main Authors: Thomann, Philipp A, Schläfer, Christine, Seidl, Ulrich, Santos, Vasco Dos, Essig, Marco, Schröder, Johannes
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Aged
Alzheimer Disease - diagnostic imaging
Alzheimer Disease - pathology
Alzheimer Disease - psychology
Alzheimer's disease
Alzheimer’s disease (AD)
Atrophy
Biological and medical sciences
Cerebellum
Cerebellum - pathology
Cognition Disorders - diagnostic imaging
Cognition Disorders - pathology
Cognition Disorders - psychology
Cognitive impairment
Cognitive performance
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Geriatrics
Humans
Image Processing, Computer-Assisted
Magnetic resonance imaging
Magnetic resonance imaging (MRI)
Magnetic Resonance Imaging - methods
Male
Medical sciences
Mild cognitive impairment (MCI)
Morphology
Neurology
Neuropsychological Tests
Organic mental disorders. Neuropsychology
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Radiography
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Summary:Abstract Neuropathological research consistently revealed the cerebellum to undergo degenerative changes in Alzheimer’s disease (AD). Whether these alterations affect cerebellar morphology in vivo has not yet been investigated in a comprehensive way. Magnetic resonance imaging was performed in 20 patients with AD, 20 with mild cognitive impairment (MCI), and 20 healthy controls. By manual tracing the cerebellum was divided in four substructures (anterior lobe, superior posterior lobe, inferior posterior lobe and corpus medullare, respectively) on each hemisphere. Posterior cerebellar lobes were significantly smaller in AD patients when compared to healthy controls. In the AD group, atrophy of the posterior cerebellar regions was associated with poorer cognitive performance. Our findings lend further support for cerebellar involvement in AD.
ISSN:0022-3956
1879-1379
DOI:10.1016/j.jpsychires.2007.12.002