Cytoplasmic and serum galectin-3 in diagnosis of thyroid malignancies

In order to address whether galectin-3 in the sera and fine needle aspirates serve as a diagnostic marker distinguishing between benign and malignant thyroid nodules, we developed an enzyme-linked immunosorbent assay. We quantified galectin-3 in fine needle aspirates from a series of 118 patients wi...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2008-11, Vol.376 (3), p.605-610
Main Authors: Inohara, Hidenori, Segawa, Tatsuya, Miyauchi, Akira, Yoshii, Tadashi, Nakahara, Susumu, Raz, Avraham, Maeda, Masahiro, Miyoshi, Eiji, Kinoshita, Noriaki, Yoshida, Hiroshi, Furukawa, Masashi, Takenaka, Yukinori, Takamura, Yuki, Ito, Yasuhiro, Taniguchi, Naoyuki
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal - immunology
Biomarkers, Tumor - analysis
Biomarkers, Tumor - blood
Biopsy, Fine-Needle
Carcinoma
Carcinoma, Papillary - diagnosis
Carcinoma, Papillary - pathology
Cytoplasm - chemistry
Enzyme-linked immunosorbent assay
Enzyme-Linked Immunosorbent Assay - methods
Galectin 3 - analysis
Galectin 3 - blood
Galectin-3
Humans
Immunochemistry
Thyroid
Thyroid Nodule - diagnosis
Thyroid Nodule - pathology
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Summary:In order to address whether galectin-3 in the sera and fine needle aspirates serve as a diagnostic marker distinguishing between benign and malignant thyroid nodules, we developed an enzyme-linked immunosorbent assay. We quantified galectin-3 in fine needle aspirates from a series of 118 patients with thyroid nodules and serum galectin-3 from another series of 46 patients, which were compared with final histology after thyroidectomy. Relative galectin-3 value (ng/mg), defined as galectin-3 concentration (ng/ml) divided by total protein concentration (mg/ml) in fine needle aspirates, was significantly higher in papillary carcinoma than in the other thyroid entities. There was no significant difference in serum galectin-3 level among patients with thyroid nodules and healthy individuals. Accordingly, relative galectin-3 value allows a definitive diagnosis of papillary carcinoma independent of cellular morphology, whereas serum galectin-3 does not serve as a marker for papillary carcinoma.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2008.09.041