Isolated cranial nerve palsies in multiple sclerosis

Abstract Data on patients with multiple sclerosis and cranial nerve involvement as a presenting sign or a sign of disease exacerbation were retrospectively analyzed. Isolated cranial nerve involvement was present in 10.4% out of 483 patients, either as a presenting symptom (7.3%) or a symptom of dis...

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Bibliographic Details
Published in:Clinical neurology and neurosurgery 2008-11, Vol.110 (9), p.886-888
Main Authors: Zadro, Ivana, Barun, Barbara, Habek, Mario, Brinar, Vesna V
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Brain - pathology
Child
Cranial Nerve Diseases - diagnosis
Cranial Nerve Diseases - etiology
Cranial nerves
Female
Humans
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Multiple sclerosis
Multiple Sclerosis - complications
Multiple Sclerosis - diagnosis
Neurology
Neurosurgery
Paralysis - etiology
Recurrence
Retrospective Studies
Spinal Cord - pathology
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Young Adult
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Summary:Abstract Data on patients with multiple sclerosis and cranial nerve involvement as a presenting sign or a sign of disease exacerbation were retrospectively analyzed. Isolated cranial nerve involvement was present in 10.4% out of 483 patients, either as a presenting symptom (7.3%) or a symptom of disease relapse (3.1%). Trigeminal nerve was most frequently involved, followed by facial, abducens, oculomotor and cochlear nerves. Only 54% of patients had brainstem MRI lesion that could explain the symptoms. As multiple sclerosis is a disease characterized by multiple neurological symptoms, while early diagnosis and therapy are critical for the prognosis and course of the disease, the diagnosis of multiple sclerosis should be considered in young adults with cranial nerve involvement.
ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2008.02.009