Recurrent Staphylococcus aureus Bacteremia: Pulsed-Field Gel Electrophoresis Findings in 29 Patients

To identify risk factors for relapse among 309 prospectively identified cases of Staphylococcus aureus bacteremia, patients with recurrent S. aureus bacteremia were identified, and pulsed-field gel electrophoresis (PFGE) was performed on isolates from both episodes. PFGE banding patterns from both i...

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Bibliographic Details
Published in:The Journal of infectious diseases 1999-05, Vol.179 (5), p.1157-1161
Main Authors: Fowler, Vance G., Li Kuo Kong, Corey, G. Ralph, Gottlieb, Geoffrey S., McClelland, R. Scott, Sexton, Daniel J., Gesty-Palmer, Diane, Harrell, Lizzie J.
Format: Article
Language:English
Subjects:
Adult
Aged
Bacteremia
Bacteremia - microbiology
Bacteremia - prevention & control
Bacterial diseases
Bacterial sepsis
Bacteriological methods and techniques used in bacteriology
Bacteriology
Biological and medical sciences
Catheters
Dialysis
DNA, Bacterial - analysis
Electrophoresis, Gel, Pulsed-Field
Female
Foreign bodies
Fundamental and applied biological sciences. Psychology
Gels
Human bacterial diseases
Humans
Infections
Infectious diseases
Major Articles
Male
Medical sciences
Microbiology
Middle Aged
Operating rooms
Prospective Studies
Recurrence
Reinfection
Relapse
Risk Factors
Staphylococcal Infections - microbiology
Staphylococcal Infections - prevention & control
Staphylococcus aureus
Staphylococcus aureus - genetics
Staphylococcus aureus - isolation & purification
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Summary:To identify risk factors for relapse among 309 prospectively identified cases of Staphylococcus aureus bacteremia, patients with recurrent S. aureus bacteremia were identified, and pulsed-field gel electrophoresis (PFGE) was performed on isolates from both episodes. PFGE banding patterns from both isolates were identical in 23 patients, consistent with relapsed infection. Patients with PFGE-confirmed relapse were more likely by both univariate and multivariate analyses to have an indwelling foreign body (odds ratio [OR] = 18.2, 95% confidence interval [CI] = 7.6-43.6; P
ISSN:0022-1899
1537-6613
DOI:10.1086/314712