Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database

We have developed a computer-based screening strategy to search the dbEST database to find differentiation antigens that are expressed by cancers arising in nonessential normal tissues such as prostate, breast, and ovary (G. Vasmatzis et al., Proc. Natl. Acad. Sci. USA, 95: 300-304, 1998). Here, we...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1999-04, Vol.59 (7), p.1445-1448
Main Authors: BRINKMANN, U, VASMATZIS, G, BYUNGKOOK LEE, PASTAN, I
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Antigens, Neoplasm - genetics
Biological and medical sciences
Databases as Topic
Gene Library
Host-tumor relations. Immunology. Biological markers
Humans
Medical sciences
Molecular Sequence Data
Neoplasm Proteins - genetics
Tumors
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Summary:We have developed a computer-based screening strategy to search the dbEST database to find differentiation antigens that are expressed by cancers arising in nonessential normal tissues such as prostate, breast, and ovary (G. Vasmatzis et al., Proc. Natl. Acad. Sci. USA, 95: 300-304, 1998). Here, we report the identification of three new members of the GAGE/ PAGE family, termed XAGEs. XAGE-1 and XAGE-2 are expressed in Ewing's sarcoma, rhabdomyosarcoma, a breast cancer, and a germ cell tumor. We also describe the relationship of the XAGEs to the GAGE/ PAGE family. XAGE-1 and XAGE-2 should be evaluated as possible targets for vaccine-based therapies of cancer.
ISSN:0008-5472
1538-7445