Dietary conjugated linoleic acid in the cis-9, trans-11 isoform reduces parathyroid hormone in male, but not female, rats

Previously, a mixture of conjugated linoleic acid (CLA) isoforms reduced parathyroid hormone (PTH) in male rats over 8 weeks. The objective herein was to determine which isoform caused the reduction in PTH; whether the effect was sex specific; and whether CLA-induced reductions in PTH were sustained...

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Bibliographic Details
Published in:The Journal of nutritional biochemistry 2008-11, Vol.19 (11), p.762-769
Main Authors: Weiler, Hope A., Fitzpatrick, Sandra, Fitzpatrick-Wong, Shirley C.
Format: Article
Language:English
Subjects:
Animal Feed
animal models
Animals
Biological and medical sciences
Biomarkers
body weight
Bone and Bones - metabolism
Bone Density
Bone mineral density
bone mineralization
calcium
Conjugated linoleic acid
dietary fat
Dinoprostone - metabolism
Feeding. Feeding behavior
Female
females
Fundamental and applied biological sciences. Psychology
gender differences
Linoleic Acids, Conjugated - chemistry
Lumbar Vertebrae - pathology
Male
males
nutrient retention
Parathyroid hormone
Parathyroid Hormone - biosynthesis
phosphorus
Protein Isoforms
Rat
Rats
Rats, Sprague-Dawley
Sex Factors
spine
stereoisomers
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Previously, a mixture of conjugated linoleic acid (CLA) isoforms reduced parathyroid hormone (PTH) in male rats over 8 weeks. The objective herein was to determine which isoform caused the reduction in PTH; whether the effect was sex specific; and whether CLA-induced reductions in PTH were sustained. Male and female weanling rats ( n=48) were randomized to a control diet or one made with 0.5% of the diet as cis-9, trans-11 (c9,t11) CLA, 0.5% of the diet as trans-10, cis-12 (t10,c12) CLA or these CLA in a mixture. Measurements made after 4, 8 and 16 weeks were body weight, bioactive PTH, ionized Ca, whole-body and regional bone mineral density (BMD) using dual-energy X-ray absorptiometry. With the use of a factorial design, a sex×c9,t11 CLA interaction was observed that reduced PTH (139.5±63.9 vs. 95.8±42.4 pg/ml, P=.02) in male rats only. No other effects of c9,t11 CLA were observed. Regarding t10,c12 CLA, no interaction effects were observed, but a main effect was observed to reduce lumbar spine BMD (0.265±0.044 vs. 0.255±0.044 g/cm 2, P
ISSN:0955-2863
1873-4847
DOI:10.1016/j.jnutbio.2007.09.010