A 1.5-Mb Contig within the Cat Eye Syndrome Critical Region at Human Chromosome 22q11.2

We have constructed a 1.5-Mb contig spanning the distal half of the critical region for cat eye syndrome on human chromosome 22 from D22S543 to D22S181. The contig consists of 20 P1 artificial chromosome (PAC) clones and 11 bacterial artificial chromosome (BAC) clones screened from 2 BAC and 2 PAC l...

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Published in:Genomics (San Diego, Calif.) Calif.), 1999-04, Vol.57 (2), p.306-309
Main Authors: Johnson, Angela, Minoshima, Shinsei, Asakawa, Shuichi, Shimizu, Nobuyoshi, Shizuya, Hiroaki, Roe, Bruce A., McDermid, Heather E.
Format: Article
Language:English
Subjects:
Abnormalities, Multiple - genetics
Bacteria - genetics
Bacteriophage P1 - genetics
Biological and medical sciences
Chromosomes, Human, Pair 22 - genetics
Coloboma - genetics
Complex syndromes
Contig Mapping
DNA - genetics
Electrophoresis, Gel, Pulsed-Field
Genetic Markers
Humans
Medical genetics
Medical sciences
Restriction Mapping
Syndrome
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cited_by cdi_FETCH-LOGICAL-c400t-20c3aaeb34f87ec143a06dad39ad83f4bf15c681eb007ba680e1edef85a9898c3
cites cdi_FETCH-LOGICAL-c400t-20c3aaeb34f87ec143a06dad39ad83f4bf15c681eb007ba680e1edef85a9898c3
container_end_page 309
container_issue 2
container_start_page 306
container_title Genomics (San Diego, Calif.)
container_volume 57
creator Johnson, Angela
Minoshima, Shinsei
Asakawa, Shuichi
Shimizu, Nobuyoshi
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Roe, Bruce A.
McDermid, Heather E.
description We have constructed a 1.5-Mb contig spanning the distal half of the critical region for cat eye syndrome on human chromosome 22 from D22S543 to D22S181. The contig consists of 20 P1 artificial chromosome (PAC) clones and 11 bacterial artificial chromosome (BAC) clones screened from 2 BAC and 2 PAC libraries. Continuous overlap between the clones was confirmed using vectorette PCR and riboprobes. Despite the instability of this region in a previous YAC contig, only 1 BAC showed a minor instability and then in only one isolation. This contig is now providing the basis for genomic sequencing and gene identification in the cat eye syndrome critical region.
doi_str_mv 10.1006/geno.1999.5757
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source ScienceDirect Freedom Collection 2022-2024
subjects Abnormalities, Multiple - genetics
Bacteria - genetics
Bacteriophage P1 - genetics
Biological and medical sciences
Chromosomes, Human, Pair 22 - genetics
Coloboma - genetics
Complex syndromes
Contig Mapping
DNA - genetics
Electrophoresis, Gel, Pulsed-Field
Genetic Markers
Humans
Medical genetics
Medical sciences
Restriction Mapping
Syndrome
title A 1.5-Mb Contig within the Cat Eye Syndrome Critical Region at Human Chromosome 22q11.2
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